年轻女性和老年女性的乳腺癌:临床病理特征比较。

Mymensingh medical journal : MMJ Pub Date : 2024-04-01
S Jahan, M M Rahman, S K Biswas, A T M Hossain, B Saha, S M A Haque
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引用次数: 0

摘要

乳腺癌是全球最常见的侵袭性癌症,女性死亡率很高。现有证据表明,年轻患者的生存率较低。因此,本研究致力于评估和对比 40 岁以下女性与年长女性乳腺癌的病理特征。本研究以横断面分析的形式进行,涵盖了在迈门辛医学院医院(MMCH)、孟加拉国社区医学院(CBMCB)和迈门辛几家私立医院就诊的 560 名乳腺癌患者。收集的数据包括年龄、居住地区、职业、肿瘤组织病理学、TNM 分类、分期和激素受体状态等信息。患者的平均年龄(标准差)为(49.7±11.9)岁,20.5%的患者年龄在40岁以下,大部分患者来自农村地区,是家庭主妇。最常见的组织病理学类型是乳腺导管癌(87.67%)。不过,与年龄较大的患者相比,年轻患者的小叶癌和其他罕见癌的发病率更高(P=0.04)。此外,年轻组的肿瘤体积更大(P=0.01),淋巴结受累(P=0.04),分期更晚(P=0.004)。值得注意的是,年龄越小,雌激素和/或孕酮受体的阴性率越高。研究结果表明,与年龄较大的女性相比,40 岁以下女性的肿瘤特征更具侵袭性,患乳腺癌的程度也更严重。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Breast Cancer in Younger and Older Women: A Comparison of Clinicopathological Traits.

Breast cancer stands as the prevailing invasive cancer globally, bearing high mortality rates among women. Existing evidence indicates diminished survival rates in younger patients. Consequently, this study endeavors to assess and contrast the pathological features of breast cancer in women under 40 years of age with their older counterparts. Conducted as a cross-sectional analysis, this study encompasses 560 patients diagnosed with breast cancer, seeking treatment at Mymensingh Medical College Hospital (MMCH), Community Based Medical College Bangladesh (CBMCB) and several private hospitals in Mymensingh. The gathered data incorporates information such as age, residential area, occupation, tumor histopathology, TNM classification, staging and status of hormone receptor. The patients' mean age (standard deviation) was 49.7±11.9 years, with 20.5% below 40, most were from rural areas and were housewives. Ductal carcinoma prevailed as the most common histopathologic type (87.67%). However, younger patients exhibited a higher prevalence of lobular and other rare carcinomas compared to their older counterparts (p=0.04). Additionally, the younger group demonstrated larger tumor sizes (p=0.01), lymphatic node involvement (p=0.04) and advanced staging (p=0.004). Notably, younger age showed more negativity for estrogen and/or progesterone receptors. The results suggested that women under 40 years old exhibit more aggressive tumor characteristics and a more severe form of breast cancer compared to their older counterparts.

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