日本新生儿重症监护室处理母乳以预防获得性巨细胞病毒感染：首次全国性调查。

IF 1 4区医学 Q3 PEDIATRICS

Pediatrics International Pub Date : 2024-01-01 DOI:10.1111/ped.15728

Kana Saito, Kosuke Tanaka, Ryota Nakagawa, Junichi Ozawa, Mitsuhiro Haga, Naoyuki Miyahara, Kazuhiko Kabe, Fumihiko Namba

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引用次数: 0

摘要

背景：人乳（HM）已被证明可为新生儿提供免疫和营养方面的益处；然而，获得性巨细胞病毒（CMV）感染可能与未加工的人乳有关。日本没有关于处理母乳的标准化指南。本横断面调查旨在揭示日本新生儿重症监护室（NICU）处理 HM 的具体趋势：方法：2020 年 5 月，我们向加入日本新生儿科医师协会的 255 个新生儿重症监护室发放了调查问卷。调查内容包括母体筛查、巴氏灭菌、储存和劳动力等 HM 处理方法：在 255 个新生儿重症监护室中，有 174 个（67.8%）对调查做出了回应。有 37 个单位（22.2%）进行了母体 CMV 筛查，有 44 个单位（26.5%）在 HM 中进行了 CMV 灭活。约 90% 的单位采用冻融法进行 CMV 灭活。在 70% 提供 CMV 灭活的单位中，无论婴儿的体重和校正胎龄如何，都会进行 CMV 灭活，直至婴儿出院。在调查期间，43 个单位（25.7%）的早产新生儿出现了获得性 CMV 感染：结论：日本新生儿重症监护室采用了多种处理 HM 的方法。结论：日本新生儿重症监护室采用的 HM 处理方法多种多样，应制定新生儿重症监护室 HM 处理国家指南，以促进 CMV 感染控制。

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Handling of human milk to prevent acquired cytomegalovirus infection in Japanese neonatal intensive care units: The first nationwide survey.

Background: Human milk (HM) has been proven to provide immunological and nutritional advantages to neonates; however, acquired cytomegalovirus (CMV) infection can be associated with raw HM. In Japan, there are no standardized guidelines concerning HM handling. This cross-sectional survey was performed to reveal specific trends in HM handling in neonatal intensive care units (NICUs) in Japan.

Methods: A questionnaire was sent to 255 NICUs participating in the Japanese Neonatologist Association in May 2020. It involved HM handling practices, such as maternal screening, pasteurization, storage, and the workforce.

Results: Of 255 NICUs, 174 (67.8%) responded to the survey. Maternal CMV screening was carried out in 37 units (22.2%), and CMV inactivation in HM was performed in 44 units (26.5%). For CMV inactivation, a freeze-thawing method was employed in about 90% of units. In 70% of units providing CMV inactivation, CMV inactivation was conducted regardless of bodyweight and corrected gestational age of infants until the infants' discharge. Acquired CMV infection in preterm neonates was observed in 43 units (25.7%) in the survey period.

Conclusion: A wide range of HM handling practices are used in Japanese NICUs. A national guideline for handling HM in NICUs should be created to promote the infection control of CMV.

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来源期刊

Pediatrics International 医学-小儿科

CiteScore

2.00

自引率

7.10%

发文量

519

审稿时长

12 months

期刊介绍： Publishing articles of scientific excellence in pediatrics and child health delivery, Pediatrics International aims to encourage those involved in the research, practice and delivery of child health to share their experiences, ideas and achievements. Formerly Acta Paediatrica Japonica, the change in name in 1999 to Pediatrics International, reflects the Journal''s international status both in readership and contributions (approximately 45% of articles published are from non-Japanese authors). The Editors continue their strong commitment to the sharing of scientific information for the benefit of children everywhere. Pediatrics International opens the door to all authors throughout the world. Manuscripts are judged by two experts solely upon the basis of their contribution of original data, original ideas and their presentation.