来自内生真菌 Talaromyces purpurpgenus 的一种三羟基萘酮衍生物和一种吡喃酮代谢物。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-05-03 DOI:10.1080/10286020.2024.2333359

Yang Liu , Ke-Liang Chen , Jing-Yi Zhao , Chen-Yu Yang , Xing-Bao Jia , Yu-Wei Niu , Ya-Nan Tian , Yang Yang , Yun-Bao Liu

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引用次数: 0

摘要

从杜鹃花内生真菌 Talaromyces purpurpgenus 中提取到了一种新发现的三羟基萘酮衍生物环氧萘酮（1），其中涉及到正羟基缩合成环氧结构，以及一种新的吡喃酮代谢物吡喃酮酸（2）。通过对这些化合物的核磁共振和 HRESIMS 数据进行综合分析，阐明了它们的结构。利用电子圆二色性（ECD）计算和 CD 光谱确定了绝对构型。值得注意的是，这些新近发现的代谢物对黄嘌呤氧化酶（XOD）具有适度的抑制活性。

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A derivative of trihydroxynaphthalenone and a pyrone metabolite from the endophytic fungus Talaromyces purpurpgenus

A newly discovered trihydroxynaphthalenone derivative, epoxynaphthalenone (1) involving the condensation of ortho-hydroxyl groups into an epoxy structure, and a novel pyrone metabolite characterized as pyroneaceacid (2), were extracted from Talaromyces purpurpgenus, an endophytic fungus residing in Rhododendron molle. The structures of these compounds were elucidated through a comprehensive analysis of their NMR and HRESIMS data. The determination of absolute configurations was accomplished using electronic circular dichroism (ECD) calculations and CD spectra. Notably, these recently identified metabolites exhibited a moderate inhibitory activity against xanthine oxidase (XOD).

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.