检查 COVID-19 疫苗接种后的先天性 FDG 积累。

IF 2.5 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Keiko Takahashi, Osamu Manabe, Kazuya Shizukuishi, Hirohumi Shibata, Hiroki Kawakami, Akira Otsuka, Noriko Oyama-Manabe
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引用次数: 0

摘要

目的:本研究旨在调查 COVID-19 疫苗引起的反应性变化的频率以及与正电子发射断层扫描(PET)/计算机断层扫描(CT)FDG 摄取增加相关的潜在因素(包括血型):我们对 2021 年 6 月至 9 月间接受 PET/CT 检查的 284 名已知有 COVID-19 疫苗接种史的患者进行了评估。我们获得了有关注射部位、疫苗类型和不良反应的信息。我们用肉眼评估了腋窝和锁骨上淋巴结以及三角肌是否有积聚。我们使用半定量分析法测定了最大标准化摄取值(SUVmax):我们的研究包括 158 名男性和 126 名女性,年龄在 16-94 岁之间。接种第一剂和第二剂疫苗的患者从接种到 PET/CT 的中位时间分别为 9 天和 42 天。我们分别在 98 例(SUVmax 1.07-25.1)、9 例(SUVmax 2.28-14.5)和 33 例(SUVmax 0.93-7.42)中观察到腋窝淋巴结、锁骨上淋巴结和三角肌积聚。在腋窝淋巴结(P = 0.0057)或三角肌(P = 0.047)积聚的病例中,接种疫苗后时间越短,FDG 积聚越高。腋窝淋巴结积聚的患者明显更年轻(P 结论:腋窝淋巴结积聚的患者明显更年轻:我们的研究发现,接种后较短时间内腋窝淋巴结和三角肌中的 FDG 积聚量较高,年轻患者、女性、有发热和肌痛不良反应的患者腋窝淋巴结积聚量较高。血型与 FDG 累积频率无明显关系。在 PET 前确认疫苗接种情况、接种后的时间以及是否存在不良反应可减少假阳性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Examination of iatrogenic FDG accumulation after COVID-19 vaccination

Purpose

This study aimed to investigate the frequency of COVID-19 vaccine-induced reactive change and potential factors including blood type correlated with increased FDG uptake on positron emission tomography (PET)/computed tomography (CT).

Materials and methods

We evaluated 284 patients who underwent PET/CT between June and September 2021 and had a known history of COVID-19 vaccination. Information on the injection site, vaccine type, and adverse reactions was obtained. We visually assessed the presence or absence of accumulation in the axillary and supraclavicular lymph nodes and the deltoid muscles. We measured the maximum standardized uptake value (SUVmax) using semi-quantitative analysis.

Results

Our study included 158 males and 126 females aged 16–94. The median time between vaccination and PET/CT was 9 and 42 days for patients who had received their first and second doses, respectively. We observed axillary lymph node accumulation, supraclavicular lymph node accumulation, and deltoid muscle accumulation in 98 (SUVmax 1.07–25.1), nine (SUVmax 2.28–14.5), and 33 cases (SUVmax 0.93–7.42), respectively. In cases with axillary lymph node (P = 0.0057) or deltoid muscle (P = 0.047) accumulation, the shorter the time since vaccination, the higher the FDG accumulation. Patients with axillary lymph node accumulation were significantly younger (P < 0.0001) and had a significantly higher frequency of adverse reactions such as fever (P < 0.0001) and myalgia (P = 0.002). No significant relationship was observed between blood type and the frequency of FDG accumulation. Logistic regression analysis also showed that age, gender, days since vaccination, and adverse reactions such as fever and myalgia were important factors for axillary lymph node accumulation.

Conclusion

Our study found that FDG accumulation in the axillary lymph nodes and deltoid muscle was higher within a shorter time after vaccination, and axillary lymph node accumulation was higher in young patients, females, and those with adverse reactions of fever and myalgia. No significant relationship was observed between blood type and the frequency of FDG accumulation. Confirming the vaccination status, time since vaccination, and the presence of adverse reactions before PET may reduce false positives.

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来源期刊
Annals of Nuclear Medicine
Annals of Nuclear Medicine 医学-核医学
CiteScore
4.90
自引率
7.70%
发文量
111
审稿时长
4-8 weeks
期刊介绍: Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine. The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.
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