开发鞣花丹宁统一合成方法。

IF 1.5 4区医学 Q4 CHEMISTRY, MEDICINAL

Chemical & pharmaceutical bulletin Pub Date : 2024-01-01 DOI:10.1248/cpb.c23-00920

Kazutada Ikeuchi

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引用次数: 0

摘要

鞣花丹宁酸是一类具有不同结构的多酚类化合物，引起了合成有机化学家的极大关注。鞣花丹宁酸的基本结构包括 D-葡萄糖与五倍子酰基或六羟基二苯甲酰基的酯，以及二芳基醚结构。因此，包括本研究小组在内的不同研究小组都开发了此类成分的合成方法。本综述介绍了我们小组在 2017-2023 年间报道的合成方法，旨在增加可化学合成的鞣花丹宁的数量。此外，还介绍了近期的相关报道。

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Development of Methodologies toward the Unified Synthesis of Ellagitannins.

Ellagitannins, a class of polyphenols with divergent structures, have attracted considerable attention from synthetic organic chemists. The basic structures in ellagitannins contain esters of D-glucose with galloyl or hexahydroxyldiphenoyl groups, as well as diaryl ether structures. Thus, the synthesis methodologies of such components have been developed by various groups, including our group. This review describes the synthetic methods reported by our group during 2017-2023, aimed at increasing the number of ellagitannins that can be chemically synthesized. In addition, recent related reports are introduced.

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来源期刊

Chemical & pharmaceutical bulletin 医学-化学综合

CiteScore

3.20

自引率

5.90%

发文量

132

审稿时长

1.7 months

期刊介绍： The CPB covers various chemical topics in the pharmaceutical and health sciences fields dealing with biologically active compounds, natural products, and medicines, while BPB deals with a wide range of biological topics in the pharmaceutical and health sciences fields including scientific research from basic to clinical studies. For details of their respective scopes, please refer to the submission topic categories below. Topics: Organic chemistry In silico science Inorganic chemistry Pharmacognosy Health statistics Forensic science Biochemistry Pharmacology Pharmaceutical care and science Medicinal chemistry Analytical chemistry Physical pharmacy Natural product chemistry Toxicology Environmental science Molecular and cellular biology Biopharmacy and pharmacokinetics Pharmaceutical education Chemical biology Physical chemistry Pharmaceutical engineering Epidemiology Hygiene Regulatory science Immunology and microbiology Clinical pharmacy Miscellaneous.