全国队列中的酒精使用障碍与特定自杀死亡方式的风险。

IF 5.3 2区 医学 Q1 PSYCHIATRY
Alexis C. Edwards, Linda Abrahamsson, Casey Crump, Jan Sundquist, Kristina Sundquist, Kenneth S. Kendler
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引用次数: 0

摘要

简介:酒精使用障碍(AUD)是自杀死亡的最主要相关因素之一,但目前还不清楚酒精使用障碍是否与特定方法导致的自杀风险存在差异:酒精使用障碍(AUD)是自杀死亡的最强相关因素之一,但目前尚不清楚AUD状况是否与特定方式的自杀风险存在不同关联:作者使用竞争风险模型评估了 AUD 状态与中毒、窒息、溺水、枪支、器械、跳楼或其他方式自杀风险之间的关联,研究对象是瑞典 1932-1995 年出生的大型队列(总人数 = 6,581,827 人;48.8% 为女性)。数据来自瑞典国家登记册,包括死因登记册和一系列医疗登记册:结果:在对社会人口因素和自杀行为的家族责任进行调整后,AUD 与每种评估方法的自杀风险都呈正相关(累积发生率差异:0.006-1.040):女性为0.006-1.040,男性为0.046-0.680),但女性与持枪自杀的相关性除外。AUD与中毒自杀风险的关系最为密切。在某些自杀方式(而非所有自杀方式)中,AUD 和家庭责任的影响存在性别差异。此外,自杀行为的高家庭责任加剧了AUD对中毒自杀(男女均有)、窒息自杀和跳楼自杀(仅男性有)风险的影响,而在持枪自杀(仅男性有)中则观察到了反向交互作用:AUD会增加所有自杀方式的自杀风险,尤其是对中毒自杀的风险影响更大。与性别和家族自杀行为相关的风险差异凸显了 AUD 在自杀风险中的微妙作用。未来的研究应调查有针对性的限制手段在 AUD 患者中的有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Alcohol use disorder and risk of specific methods of suicide death in a national cohort

Alcohol use disorder and risk of specific methods of suicide death in a national cohort

Introduction

Alcohol use disorder (AUD) is among the strongest correlates of suicide death, but it is unclear whether AUD status is differentially associated with risk of suicide by particular methods.

Methods

The authors used competing risks models to evaluate the association between AUD status and risk of suicide by poisoning, suffocation, drowning, firearm, instruments, jumping, or other means in a large Swedish cohort born 1932–1995 (total N = 6,581,827; 48.8% female). Data were derived from Swedish national registers, including the Cause of Death Register and a range of medical registers.

Results

After adjusting for sociodemographic factors and familial liability to suicidal behavior, AUD was positively associated with risk of suicide for each method evaluated (cumulative incidence differences: 0.006–1.040 for females, 0.046–0.680 for males), except the association with firearm suicide in females. AUD was most strongly associated with risk of suicide by poisoning. Sex differences in the effects of AUD and family liability were observed for some, but not all, methods. Furthermore, high familial liability for suicidal behavior exacerbated AUD's impact on risk for suicide by poisoning (both sexes) and suffocation and jumping (males only), while the inverse interaction was observed for firearm suicide (males only).

Conclusions

AUD increases risk of suicide by all methods examined and is particularly potent with respect to risk of suicide by poisoning. Differences in risk related to sex and familial liability to suicidal behavior underscore AUD's nuanced role in suicide risk. Future research should investigate targeted means restriction effectiveness among persons with AUD.

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来源期刊
Acta Psychiatrica Scandinavica
Acta Psychiatrica Scandinavica 医学-精神病学
CiteScore
11.20
自引率
3.00%
发文量
135
审稿时长
6-12 weeks
期刊介绍: Acta Psychiatrica Scandinavica acts as an international forum for the dissemination of information advancing the science and practice of psychiatry. In particular we focus on communicating frontline research to clinical psychiatrists and psychiatric researchers. Acta Psychiatrica Scandinavica has traditionally been and remains a journal focusing predominantly on clinical psychiatry, but translational psychiatry is a topic of growing importance to our readers. Therefore, the journal welcomes submission of manuscripts based on both clinical- and more translational (e.g. preclinical and epidemiological) research. When preparing manuscripts based on translational studies for submission to Acta Psychiatrica Scandinavica, the authors should place emphasis on the clinical significance of the research question and the findings. Manuscripts based solely on preclinical research (e.g. animal models) are normally not considered for publication in the Journal.
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