荨麻疹的免疫发病机制:组胺和细胞因子参与的临床视角。

IF 4.8 3区 医学 Q2 CELL BIOLOGY
Inflammation Research Pub Date : 2024-05-01 Epub Date: 2024-03-31 DOI:10.1007/s00011-024-01869-6
Rudranil Bhowmik, Md Adil Shaharyar, Arnab Sarkar, Avishek Mandal, Kumar Anand, Humira Shabana, Achintya Mitra, Sanmoy Karmakar
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引用次数: 0

摘要

背景:荨麻疹是一种临床症状,其特征是出现喘息(荨麻疹)、血管性水肿或两者兼而有之。过去几十年来,随着对荨麻疹免疫发病机制的深入了解,人们发现荨麻疹存在多种亚型。明确区分不同类型的荨麻疹有助于找到治疗这种皮肤病的最佳检测方法。荨麻疹的亚型还包括自发性和物理性两种类型。传统的荨麻疹包括自发性荨麻疹、急性荨麻疹和慢性荨麻疹。因此,广泛而有效的治疗对于荨麻疹的诊断和治疗至关重要:为了了解荨麻疹的免疫发病机制,我们使用了各种数据库,包括 PubMed、Scopus 和 Web of Science,检索与荨麻疹相关的原创文章和综述。此外,还从 clinicaltrials.gov 数据库中获取了几项临床试验的信息:本文重点介绍了荨麻疹病理生理学中细胞浸润、免疫反应、凝血级联和自身抗体之间错综复杂的相互作用所涉及的免疫发病机制:结论:近年来在了解荨麻疹方面取得的进展有助于理解荨麻疹免疫发病机制中错综复杂的特点,并可在荨麻疹的治疗中发挥有益作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Immunopathogenesis of urticaria: a clinical perspective on histamine and cytokine involvement.

Background: Urticaria is a clinical condition characterized by the appearance of wheals (hives), angioedema, or both. Over the last several decades, a better understanding of the mechanisms at play in the immunopathogenesis of urticaria has underscored the existence of numerous urticaria subtypes. Separating the different kinds of urticaria explicitly helps find the best detection method for the management of this skin disorder. Subtypes of urticaria also include both spontaneous and physical types. The conventional ones include spontaneous urticaria, constituting both acute and chronic urticaria. Therefore, a broad and effective therapy is essential for the diagnosis and treatment of urticaria.

Methods: To understand the immunopathogenesis of urticaria, various databases, including PubMed, Scopus, and Web of Science, were used to retrieve original articles and reviews related to urticaria. While information on several clinical trials were obtained from clinicaltrials.gov database.

Results: This article highlights the immunopathogenesis involved in the intricate interaction between cellular infiltration, immune reactions, coagulation cascades, and autoantibodies that underlie urticaria's pathophysiology.

Conclusion: The recent progress in understanding urticaria can help to understand the intricate characteristics in the immunopathogenesis of urticaria and could play a beneficial role in the management of urticaria.

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来源期刊
Inflammation Research
Inflammation Research 医学-免疫学
CiteScore
9.90
自引率
1.50%
发文量
134
审稿时长
3-8 weeks
期刊介绍: Inflammation Research (IR) publishes peer-reviewed papers on all aspects of inflammation and related fields including histopathology, immunological mechanisms, gene expression, mediators, experimental models, clinical investigations and the effect of drugs. Related fields are broadly defined and include for instance, allergy and asthma, shock, pain, joint damage, skin disease as well as clinical trials of relevant drugs.
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