Ines Foessl, Cheryl L Ackert-Bicknell, Erika Kague, Faidra Laskou, Franz Jakob, David Karasik, Barbara Obermayer-Pietsch, Nerea Alonso, Åshild Bjørnerem, Maria Luisa Brandi, Björn Busse, Ângelo Calado, Alper Han Cebi, Maria Christou, Kathleen M Curran, Jannie Dahl Hald, Maria Donatella Semeraro, Eleni Douni, Emma L Duncan, Ivan Duran, Melissa M Formosa, Yankel Gabet, Samuel Ghatan, Artemis Gkitakou, Eva Maria Hassler, Wolfgang Högler, Terhi J Heino, Gretl Hendrickx, Patricia Khashayar, Douglas P Kiel, Fjorda Koromani, Bente Langdahl, Philippe Lopes, Outi Mäkitie, Antonio Maurizi, Carolina Medina-Gomez, Evangelia Ntzani, Claes Ohlsson, Vid Prijatelj, Raquel Rabionet, Sjur Reppe, Fernando Rivadeneira, Gennady Roshchupkin, Neha Sharma, Kent Søe, Unnur Styrkarsdottir, Pavel Szulc, Anna Teti, Jon Tobias, Amina Valjevac, Jeroen van de Peppel, Bram van der Eerden, Bert van Rietbergen, Tatjana Zekic, M Carola Zillikens
{"title":"肌肉骨骼研究中的肌肉表型透视。","authors":"Ines Foessl, Cheryl L Ackert-Bicknell, Erika Kague, Faidra Laskou, Franz Jakob, David Karasik, Barbara Obermayer-Pietsch, Nerea Alonso, Åshild Bjørnerem, Maria Luisa Brandi, Björn Busse, Ângelo Calado, Alper Han Cebi, Maria Christou, Kathleen M Curran, Jannie Dahl Hald, Maria Donatella Semeraro, Eleni Douni, Emma L Duncan, Ivan Duran, Melissa M Formosa, Yankel Gabet, Samuel Ghatan, Artemis Gkitakou, Eva Maria Hassler, Wolfgang Högler, Terhi J Heino, Gretl Hendrickx, Patricia Khashayar, Douglas P Kiel, Fjorda Koromani, Bente Langdahl, Philippe Lopes, Outi Mäkitie, Antonio Maurizi, Carolina Medina-Gomez, Evangelia Ntzani, Claes Ohlsson, Vid Prijatelj, Raquel Rabionet, Sjur Reppe, Fernando Rivadeneira, Gennady Roshchupkin, Neha Sharma, Kent Søe, Unnur Styrkarsdottir, Pavel Szulc, Anna Teti, Jon Tobias, Amina Valjevac, Jeroen van de Peppel, Bram van der Eerden, Bert van Rietbergen, Tatjana Zekic, M Carola Zillikens","doi":"10.1016/j.tem.2024.01.004","DOIUrl":null,"url":null,"abstract":"<p><p>Musculoskeletal research should synergistically investigate bone and muscle to inform approaches for maintaining mobility and to avoid bone fractures. The relationship between sarcopenia and osteoporosis, integrated in the term 'osteosarcopenia', is underscored by the close association shown between these two conditions in many studies, whereby one entity emerges as a predictor of the other. In a recent workshop of Working Group (WG) 2 of the EU Cooperation in Science and Technology (COST) Action 'Genomics of MusculoSkeletal traits Translational Network' (GEMSTONE) consortium (CA18139), muscle characterization was highlighted as being important, but currently under-recognized in the musculoskeletal field. Here, we summarize the opinions of the Consortium and research questions around translational and clinical musculoskeletal research, discussing muscle phenotyping in human experimental research and in two animal models: zebrafish and mouse.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"478-489"},"PeriodicalIF":11.4000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A perspective on muscle phenotyping in musculoskeletal research.\",\"authors\":\"Ines Foessl, Cheryl L Ackert-Bicknell, Erika Kague, Faidra Laskou, Franz Jakob, David Karasik, Barbara Obermayer-Pietsch, Nerea Alonso, Åshild Bjørnerem, Maria Luisa Brandi, Björn Busse, Ângelo Calado, Alper Han Cebi, Maria Christou, Kathleen M Curran, Jannie Dahl Hald, Maria Donatella Semeraro, Eleni Douni, Emma L Duncan, Ivan Duran, Melissa M Formosa, Yankel Gabet, Samuel Ghatan, Artemis Gkitakou, Eva Maria Hassler, Wolfgang Högler, Terhi J Heino, Gretl Hendrickx, Patricia Khashayar, Douglas P Kiel, Fjorda Koromani, Bente Langdahl, Philippe Lopes, Outi Mäkitie, Antonio Maurizi, Carolina Medina-Gomez, Evangelia Ntzani, Claes Ohlsson, Vid Prijatelj, Raquel Rabionet, Sjur Reppe, Fernando Rivadeneira, Gennady Roshchupkin, Neha Sharma, Kent Søe, Unnur Styrkarsdottir, Pavel Szulc, Anna Teti, Jon Tobias, Amina Valjevac, Jeroen van de Peppel, Bram van der Eerden, Bert van Rietbergen, Tatjana Zekic, M Carola Zillikens\",\"doi\":\"10.1016/j.tem.2024.01.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Musculoskeletal research should synergistically investigate bone and muscle to inform approaches for maintaining mobility and to avoid bone fractures. 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A perspective on muscle phenotyping in musculoskeletal research.
Musculoskeletal research should synergistically investigate bone and muscle to inform approaches for maintaining mobility and to avoid bone fractures. The relationship between sarcopenia and osteoporosis, integrated in the term 'osteosarcopenia', is underscored by the close association shown between these two conditions in many studies, whereby one entity emerges as a predictor of the other. In a recent workshop of Working Group (WG) 2 of the EU Cooperation in Science and Technology (COST) Action 'Genomics of MusculoSkeletal traits Translational Network' (GEMSTONE) consortium (CA18139), muscle characterization was highlighted as being important, but currently under-recognized in the musculoskeletal field. Here, we summarize the opinions of the Consortium and research questions around translational and clinical musculoskeletal research, discussing muscle phenotyping in human experimental research and in two animal models: zebrafish and mouse.
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Trends in Endocrinology and Metabolism (TEM) stands as a premier Reviews journal in the realms of metabolism and endocrinology. Our commitment is reflected in the publication of refined, concise, and highly impactful articles that delve into cutting-edge topics, encompassing basic, translational, and clinical aspects. From state-of-the-art treatments for endocrine diseases to groundbreaking developments in molecular biology, TEM provides comprehensive coverage.
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