一家三级炎症性肠病中心早期细胞疗法临床试验的患者参与度和满意度。

IF 5.9 2区 医学 Q1 CELL & TISSUE ENGINEERING
Stem Cell Reports Pub Date : 2024-04-09 Epub Date: 2024-03-28 DOI:10.1016/j.stemcr.2024.02.008
Megan Obi, Ashley Adams, Alexandria Vandenbossche, Ana Otero Pineiro, Amy L Lightner
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引用次数: 0

摘要

目前正在进行几项研究细胞和基因疗法的临床试验,虽然这些试验旨在对患者护理产生重大影响,但它们有赖于患者的参与和介入。遗憾的是,临床试验通常需要受试者的广泛参与。虽然有几项研究正在使用经过验证的调查来衡量患者报告的结果,但缺乏对患者在这些试验中作为受试者的经历的描述。因此,我们对间充质基质细胞(MSC)试验参与者进行了调查,以了解他们的观点。我们发现,患者需要依赖胃肠病学家和结直肠外科医生介绍试验,而时间和费用是参与试验的主要障碍。总体而言,参与者对参与间充质干细胞试验的满意度很高,但未来的方案可以更多地使用虚拟预约来优化患者体验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Patient engagement and satisfaction with early phase cell therapy clinical trials at a tertiary inflammatory bowel disease center.

Several clinical trials are underway investigating cell and gene therapy, and while these trials are meant to significantly impact patient care, they rely on patient engagement and participation. Unfortunately, clinical trials generally require extensive commitment by subjects. While several studies are using validated surveys to measure patient-reported outcomes, there is a lack of characterization of the patient experience as a subject in these trials. As such, we surveyed mesenchymal stromal cell (MSC) trial participants to understand their perspective. We found that there exists a reliance on one's gastroenterologist and colorectal surgeons for trial introduction and that time and cost were the main barriers to participation. Overall, participants demonstrated high satisfaction with MSC trial participation, but future protocols could incorporate increased use of virtual appointments to optimize patient experience.

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来源期刊
Stem Cell Reports
Stem Cell Reports CELL & TISSUE ENGINEERING-CELL BIOLOGY
CiteScore
10.50
自引率
1.70%
发文量
200
审稿时长
28 weeks
期刊介绍: Stem Cell Reports publishes high-quality, peer-reviewed research presenting conceptual or practical advances across the breadth of stem cell research and its applications to medicine. Our particular focus on shorter, single-point articles, timely publication, strong editorial decision-making and scientific input by leaders in the field and a "scoop protection" mechanism are reasons to submit your best papers.
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