现有总抗毒素 B IgG 免疫力对艰难梭菌复发感染结果的影响。

IF 2.5 3区生物学 Q3 MICROBIOLOGY

Anaerobe Pub Date : 2024-03-28 DOI:10.1016/j.anaerobe.2024.102842

Isaura Rigo, Mary K. Young, Mayuresh M. Abhyankar, Feifan Xu, Girija Ramakrishnan, Farha Naz, Gregory R. Madden , William A. Petri

{"title":"现有总抗毒素 B IgG 免疫力对艰难梭菌复发感染结果的影响。","authors":"Isaura Rigo, Mary K. Young, Mayuresh M. Abhyankar, Feifan Xu, Girija Ramakrishnan, Farha Naz, Gregory R. Madden , William A. Petri","doi":"10.1016/j.anaerobe.2024.102842","DOIUrl":null,"url":null,"abstract":"<div><p>Late anti-toxin-B humoral immunity acquired after treatment is important for preventing recurrent <em>Clostridioides difficile</em> infection. We prospectively-measured anti-toxin-B IgG and neutralization titers at diagnosis as potential early predictors of recurrence. High anti-toxin-B-IgG/neutralizing antibodies were associated with short-lasting protection within 6-weeks, however, no difference in recurrence risk was observed by 90-days post-infection.</p></div>","PeriodicalId":8050,"journal":{"name":"Anaerobe","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1075996424000258/pdfft?md5=0f538c143729db31974658bf8b4a2a0a&pid=1-s2.0-S1075996424000258-main.pdf","citationCount":"0","resultStr":"{\"title\":\"The impact of existing total anti-toxin B IgG immunity in outcomes of recurrent Clostridioides difficile infection\",\"authors\":\"Isaura Rigo, Mary K. Young, Mayuresh M. Abhyankar, Feifan Xu, Girija Ramakrishnan, Farha Naz, Gregory R. Madden , William A. Petri\",\"doi\":\"10.1016/j.anaerobe.2024.102842\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Late anti-toxin-B humoral immunity acquired after treatment is important for preventing recurrent <em>Clostridioides difficile</em> infection. We prospectively-measured anti-toxin-B IgG and neutralization titers at diagnosis as potential early predictors of recurrence. High anti-toxin-B-IgG/neutralizing antibodies were associated with short-lasting protection within 6-weeks, however, no difference in recurrence risk was observed by 90-days post-infection.</p></div>\",\"PeriodicalId\":8050,\"journal\":{\"name\":\"Anaerobe\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-03-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1075996424000258/pdfft?md5=0f538c143729db31974658bf8b4a2a0a&pid=1-s2.0-S1075996424000258-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Anaerobe\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1075996424000258\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Anaerobe","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1075996424000258","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MICROBIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

治疗后获得的晚期抗毒素-B 体液免疫对预防艰难梭菌感染复发非常重要。我们对诊断时的抗毒素-B IgG 和中和滴度进行了前瞻性测定，以此作为复发的潜在早期预测指标。高抗毒素-B-IgG/中和抗体与6周内的短效保护有关，但在感染后90天内没有观察到复发风险的差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

The impact of existing total anti-toxin B IgG immunity in outcomes of recurrent Clostridioides difficile infection

Late anti-toxin-B humoral immunity acquired after treatment is important for preventing recurrent Clostridioides difficile infection. We prospectively-measured anti-toxin-B IgG and neutralization titers at diagnosis as potential early predictors of recurrence. High anti-toxin-B-IgG/neutralizing antibodies were associated with short-lasting protection within 6-weeks, however, no difference in recurrence risk was observed by 90-days post-infection.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Anaerobe 生物-微生物学

CiteScore

5.20

自引率

8.70%

发文量

137

审稿时长

76 days

期刊介绍： Anaerobe is essential reading for those who wish to remain at the forefront of discoveries relating to life processes of strictly anaerobes. The journal is multi-disciplinary, and provides a unique forum for those investigating anaerobic organisms that cause infections in humans and animals, as well as anaerobes that play roles in microbiomes or environmental processes. Anaerobe publishes reviews, mini reviews, original research articles, notes and case reports. Relevant topics fall into the broad categories of anaerobes in human and animal diseases, anaerobes in the microbiome, anaerobes in the environment, diagnosis of anaerobes in clinical microbiology laboratories, molecular biology, genetics, pathogenesis, toxins and antibiotic susceptibility of anaerobic bacteria.