血液培养中肺炎克雷伯菌阳性时间作为腹腔内感染患者的预后指标:一项回顾性研究。

IF 5.5 1区 农林科学 Q1 IMMUNOLOGY
Virulence Pub Date : 2024-12-01 Epub Date: 2024-03-28 DOI:10.1080/21505594.2024.2329397
Yong-Ye Yang, I-Ting Tsai, Chung-Hsu Lai, Chih-Ping Chen, Chia-Chi Chen, Yin-Chou Hsu
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引用次数: 0

摘要

肺炎克雷伯菌是腹腔内感染并发菌血症的常见致病菌,可导致严重的死亡风险。血液培养阳性时间(TTP)被认为是其他菌种引起的菌血症的预后因素。因此,本研究旨在探讨 TTP 在这些患者中的预后价值。这项单中心、回顾性、观察性队列研究在2016年7月1日至2021年6月30日期间进行。所有在此期间确诊为腹腔内感染并进行了血液培养的成人急诊患者均被纳入研究。研究共纳入了 196 名患者。30 天总死亡率为 12.2%(24/196),研究队列的中位 TTP 为 12.3 小时(10.5-15.8 小时)。TTP显示了中等程度的30天死亡率判别能力(曲线下面积0.73,p 12小时,N = 109),早期TTP(≤12小时,N = 87)组患者的30天死亡风险显著较高(21.8% vs. 4.6%,p p = 0.02),Pitt菌血症评分(OR = 1.30,p = 0.03),实施源头控制(OR = 0.06,p K.肺炎菌血症)。因此,医生可以使用 TTP 对这些患者的预后进行分层。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Time to positivity of Klebsiella pneumoniae in blood cultures as prognostic marker in patients with intra-abdominal infection: A retrospective study.

Klebsiella pneumoniae is a common causative pathogen of intra-abdominal infection with concomitant bacteraemia, leading to a significant mortality risk. The time to positivity (TTP) of blood culture is postulated to be a prognostic factor in bacteraemia caused by other species. Therefore, this study aimed to investigate the prognostic value of TTP in these patients. The single-centred, retrospective, observational cohort study was conducted between 1 July 2016 and 30 June 2021. All adult emergency department patients with diagnosis of intra-abdominal infection and underwent blood culture collection which yield K. pneumoniae during this period were enrolled. A total of 196 patients were included in the study. The overall 30-day mortality rate was 12.2% (24/196), and the median TTP of the studied cohort was 12.3 h (10.5-15.8 h). TTP revealed a moderate 30-day mortality discriminative ability (area under the curve 0.73, p < 0.001). Compared with the late TTP group (>12 h, N = 109), patients in the early TTP (≤12 h, N = 87) group had a significantly higher risk of 30-day morality (21.8% vs. 4.6%, p < 0.01) and other adverse outcomes. Furthermore, TTP (odds ratio [OR] = 0.79, p = 0.02), Pitt bacteraemia score (OR = 1.30, p = 0.03), and implementation of source control (OR = 0.06, p < 0.01) were identified as independent factors related to 30-day mortality risk in patients with intra-abdominal infection and K. pneumoniae bacteraemia. Therefore, physicians can use TTP for prognosis stratification in these patients.

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来源期刊
Virulence
Virulence IMMUNOLOGY-MICROBIOLOGY
CiteScore
9.20
自引率
1.90%
发文量
123
审稿时长
6-12 weeks
期刊介绍: Virulence is a fully open access peer-reviewed journal. All articles will (if accepted) be available for anyone to read anywhere, at any time immediately on publication. Virulence is the first international peer-reviewed journal of its kind to focus exclusively on microbial pathogenicity, the infection process and host-pathogen interactions. To address the new infectious challenges, emerging infectious agents and antimicrobial resistance, there is a clear need for interdisciplinary research.
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