染色质结构相关生物大分子的相分离:表观遗传调控的驱动力。

IF 1.9 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Jiao Wang, Yuchen Chen, Zixuan Xiao, Xikai Liu, Chengyu Liu, Kun Huang, Hong Chen
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引用次数: 0

摘要

在细胞内,无膜细胞器是由大分子自发融合和分裂形成的,这一过程被称为相分离,在细胞活动中发挥着重要作用。在某些疾病状态下,如癌症和神经退行性疾病,会发生异常的相分离,并参与疾病的进展。染色质结构相关蛋白会根据自身特性和外部刺激进行相分离,从而发挥基因组组装、转录调控和信号转导等功能。此外,许多染色质结构相关蛋白,如组蛋白、组蛋白修饰酶、DNA修饰酶和DNA甲基化结合蛋白等,通过相分离参与表观遗传调控。本综述以染色质结构相关分子为重点,介绍相分离以及相分离如何影响表观遗传学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Phase Separation of Chromatin Structure-related Biomolecules: A Driving Force for Epigenetic Regulations.

Intracellularly, membrane-less organelles are formed by spontaneous fusion and fission of macro-molecules in a process called phase separation, which plays an essential role in cellular activities. In certain disease states, such as cancers and neurodegenerative diseases, aberrant phase separations take place and participate in disease progression. Chromatin structure-related proteins, based on their characteristics and upon external stimuli, phase separate to exert functions like genome assembly, transcription regulation, and signal transduction. Moreover, many chromatin structure-related proteins, such as histones, histone-modifying enzymes, DNA-modifying enzymes, and DNA methylation binding proteins, are involved in epigenetic regulations through phase separation. This review introduces phase separation and how phase separation affects epigenetics with a focus on chromatin structure-related molecules.

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来源期刊
Current protein & peptide science
Current protein & peptide science 生物-生化与分子生物学
CiteScore
5.20
自引率
0.00%
发文量
73
审稿时长
6 months
期刊介绍: Current Protein & Peptide Science publishes full-length/mini review articles on specific aspects involving proteins, peptides, and interactions between the enzymes, the binding interactions of hormones and their receptors; the properties of transcription factors and other molecules that regulate gene expression; the reactions leading to the immune response; the process of signal transduction; the structure and function of proteins involved in the cytoskeleton and molecular motors; the properties of membrane channels and transporters; and the generation and storage of metabolic energy. In addition, reviews of experimental studies of protein folding and design are given special emphasis. Manuscripts submitted to Current Protein and Peptide Science should cover a field by discussing research from the leading laboratories in a field and should pose questions for future studies. Original papers, research articles and letter articles/short communications are not considered for publication in Current Protein & Peptide Science.
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