Haishuang Wang, Hongbo Xu, Huanle Shu, Shi Xu, Wei Wang
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Correlations between stress hormone levels and AIS-ISS were discussed. The predictive effects of AIS-ISS and stress hormones on API occurrence in trauma patients were analyzed using receiver operating characteristic (ROC) curves. The relationship between stress hormone levels and API severity was also observed.</p><p><strong>Results: </strong>Study's outcomes indicated distinct relationships between stress hormone levels and API occurrence in trauma patients. Specifically, INS demonstrated a negative correlation with AIS-ISS, highlighting its potential as a significant factor. Glu, Cort, and FBG revealed positive associations, emphasizing their roles in influencing API development (P < .05). The diagnostic efficacy of stress hormones in predicting API occurrence, as represented by the Area Under Curve (AUC) = 0.8100. Notably, within the API group, INS levels demonstrated a decline with worsening API. Conversely, Glu, Cort, and FBG exhibited increases in tandem with the aggravation of API symptoms (P < .05).</p><p><strong>Conclusions: </strong>This research suggests that assessing stress hormone levels in clinical settings can effectively predict API occurrence. 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引用次数: 0
摘要
研究目的本研究探讨创伤患者体内胰岛素（INS）、空腹血糖（FBG）、胰高血糖素（Glu）和皮质醇（Cort）等应激激素的动态变化。通过监测这些变化和观察皮肤上的急性压力损伤（API）发生情况，该研究分析了应激激素对创伤患者 API 发生的影响：方法：对2021年4月至2023年6月期间温州市一家三级甲等综合医院收治的218例创伤患者进行前瞻性分析。其中44例出现API（API组），174例未出现API（对照组）。两组均测量了 INS、Cort、Glu 和 FBG 水平。此外，还进行了简略损伤量表-损伤严重程度评分（AIS-ISS）调查和 API 严重程度评估。讨论了应激激素水平与 AIS-ISS 之间的相关性。使用接收器操作特征曲线（ROC）分析了 AIS-ISS 和应激激素对创伤患者 API 发生率的预测作用。此外，还观察了应激激素水平与 API 严重程度之间的关系：研究结果表明，创伤患者的应激激素水平与 API 发生率之间存在明显的关系。具体而言，INS 与 AIS-ISS 呈负相关，突出了其作为重要因素的潜力。Glu、Cort和FBG呈正相关，强调了它们在影响API发展中的作用（P < .05）。曲线下面积（AUC）= 0.8100 表明应激激素在预测 API 发生方面具有诊断功效。值得注意的是，在 API 组中，INS 水平随着 API 的恶化而下降。相反，Glu、Cort 和 FBG 则随着 API 症状的加重而增加（P < .05）：这项研究表明，在临床环境中评估应激激素水平可有效预测 API 的发生。早期检测有助于制定预防或干预措施，减少创伤患者 API 的发生率和危害。
Assessment of the Significance and Clinical Implications of Stress Hormones in Acute Pressure Injuries Among Trauma Patients.
Objective: This study examines the dynamic changes of stress hormones, including insulin (INS), fasting blood glucose (FBG), glucagon (Glu), and cortisol (Cort), in trauma patients. By monitoring these changes and observing acute pressure injury (API) occurrences on the skin, the research analyzes the influence of stress hormones on API development in trauma patients.
Methods: A prospective analysis involved 218 trauma patients admitted to a grade III-A general hospital in Wenzhou from April 2021 to June 2023. Among them, 44 cases developed API (API group), and 174 cases did not (control group). Levels of INS, Cort, Glu, and FBG were measured in both groups. Additionally, Abbreviated Injury Scale-Injury Severity Score (AIS-ISS) surveys and API severity assessments were conducted. Correlations between stress hormone levels and AIS-ISS were discussed. The predictive effects of AIS-ISS and stress hormones on API occurrence in trauma patients were analyzed using receiver operating characteristic (ROC) curves. The relationship between stress hormone levels and API severity was also observed.
Results: Study's outcomes indicated distinct relationships between stress hormone levels and API occurrence in trauma patients. Specifically, INS demonstrated a negative correlation with AIS-ISS, highlighting its potential as a significant factor. Glu, Cort, and FBG revealed positive associations, emphasizing their roles in influencing API development (P < .05). The diagnostic efficacy of stress hormones in predicting API occurrence, as represented by the Area Under Curve (AUC) = 0.8100. Notably, within the API group, INS levels demonstrated a decline with worsening API. Conversely, Glu, Cort, and FBG exhibited increases in tandem with the aggravation of API symptoms (P < .05).
Conclusions: This research suggests that assessing stress hormone levels in clinical settings can effectively predict API occurrence. Early testing could aid in the development of preventive or intervention measures, reducing the incidence and harm of API in trauma patients.
期刊介绍：
Launched in 1995, Alternative Therapies in Health and Medicine has a mission to promote the art and science of integrative medicine and a responsibility to improve public health. We strive to maintain the highest standards of ethical medical journalism independent of special interests that is timely, accurate, and a pleasure to read. We publish original, peer-reviewed scientific articles that provide health care providers with continuing education to promote health, prevent illness, and treat disease. Alternative Therapies in Health and Medicine was the first journal in this field to be indexed in the National Library of Medicine. In 2006, 2007, and 2008, ATHM had the highest impact factor ranking of any independently published peer-reviewed CAM journal in the United States—meaning that its research articles were cited more frequently than any other journal’s in the field.
Alternative Therapies in Health and Medicine does not endorse any particular system or method but promotes the evaluation and appropriate use of all effective therapeutic approaches. Each issue contains a variety of disciplined inquiry methods, from case reports to original scientific research to systematic reviews. The editors encourage the integration of evidence-based emerging therapies with conventional medical practices by licensed health care providers in a way that promotes a comprehensive approach to health care that is focused on wellness, prevention, and healing. Alternative Therapies in Health and Medicine hopes to inform all licensed health care practitioners about developments in fields other than their own and to foster an ongoing debate about the scientific, clinical, historical, legal, political, and cultural issues that affect all of health care.
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