A. A. Voronova, A. V. Naumkin, A. Yu. Pereyaslavtsev, T. Batsalova, B. Dzhambazov, A. Yu. Vasil’kov
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Effect of the Solvent Nature on the Biological Activity of Gold-Containing Systems
Gold nanoparticles were prepared by metal vapor synthesis using isopropyl alcohol, acetone, and toluene as dispersion media. The electronic states of the metal and the nature of the adsorbed layer on the nanoparticle surface were investigated. Analysis of the photoelectron spectra of the obtained nanoparticles showed that regardless of the synthesis conditions, gold occurs in the Au0, Au+, and Au3+ states in all samples, and a carbon-containing shell is present on all types of metal particles. A study of the anticancer activity of nanoparticles in vitro using human cell lines revealed a dependence of the biological activity on the exposure time for samples obtained in a toluene dispersion medium. The metabolic activity of cancer cells treated with gold nanoparticles formed in isopropyl alcohol or acetone dropped in the very beginning of testing.
期刊介绍：
Doklady Physical Chemistry is a monthly journal containing English translations of current Russian research in physical chemistry from the Physical Chemistry sections of the Doklady Akademii Nauk (Proceedings of the Russian Academy of Sciences). The journal publishes the most significant new research in physical chemistry being done in Russia, thus ensuring its scientific priority. Doklady Physical Chemistry presents short preliminary accounts of the application of the state-of-the-art physical chemistry ideas and methods to the study of organic and inorganic compounds and macromolecules; polymeric, inorganic and composite materials as well as corresponding processes. The journal is intended for scientists in all fields of chemistry and in interdisciplinary sciences.
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