评估运动性脊髓完全损伤患者的肾功能--将胱抑素 C 作为准确的单一标记物

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Spinal cord Pub Date : 2024-03-28 DOI:10.1038/s41393-024-00973-y

Thomas Anand Augustine, Henry Prakash M, Suceena Alexander, Mahasampath Gowri S

{"title":"评估运动性脊髓完全损伤患者的肾功能--将胱抑素 C 作为准确的单一标记物","authors":"Thomas Anand Augustine, Henry Prakash M, Suceena Alexander, Mahasampath Gowri S","doi":"10.1038/s41393-024-00973-y","DOIUrl":null,"url":null,"abstract":"Observational cohort. To show that Cystatin C is an accurate single marker to estimate GFR in motor complete persons with SCI. To assess if Cystatin C is an accurate for estimating GFR in persons with SCI with no preserved motor power. To study if use of Serum creatinine for estimation of GFR in this population significantly overestimates GFR, thereby inaccurate. Tertiary care hospital and Medical College, Vellore, South India. 30 persons with SCI (ASIA A and B) fulfilling the inclusion criteria were recruited. Serum Creatinine and Serum Cystatin C values were obtained, and eGFR was calculated based on available formulae. 24-h urine for urine creatinine clearance-based eGFR was used as a reference value. Analysis with a Bland-Atman plot showed that eGFR estimated with Serum Cystatin C was more accurate than Serum Creatinine, using 24-h urine creatinine as a reference value. eGFR using Serum Creatinine significantly overestimated GFR by over 50.6%. Estimated GFR using Serum Cystatin C showed a meager mean difference of 0.5% from the reference 24-h urine creatinine clearance (mean difference of –2.56%). Serum Cystatin C is a much more accurate marker for estimating GFR in SCI, compared to serum Creatinine which overestimates GFR.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"62 6","pages":"295-299"},"PeriodicalIF":2.1000,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Assessment of renal function in persons with motor complete spinal cord injury—cystatin C as an accurate single marker\",\"authors\":\"Thomas Anand Augustine, Henry Prakash M, Suceena Alexander, Mahasampath Gowri S\",\"doi\":\"10.1038/s41393-024-00973-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Observational cohort. To show that Cystatin C is an accurate single marker to estimate GFR in motor complete persons with SCI. To assess if Cystatin C is an accurate for estimating GFR in persons with SCI with no preserved motor power. To study if use of Serum creatinine for estimation of GFR in this population significantly overestimates GFR, thereby inaccurate. Tertiary care hospital and Medical College, Vellore, South India. 30 persons with SCI (ASIA A and B) fulfilling the inclusion criteria were recruited. Serum Creatinine and Serum Cystatin C values were obtained, and eGFR was calculated based on available formulae. 24-h urine for urine creatinine clearance-based eGFR was used as a reference value. Analysis with a Bland-Atman plot showed that eGFR estimated with Serum Cystatin C was more accurate than Serum Creatinine, using 24-h urine creatinine as a reference value. eGFR using Serum Creatinine significantly overestimated GFR by over 50.6%. Estimated GFR using Serum Cystatin C showed a meager mean difference of 0.5% from the reference 24-h urine creatinine clearance (mean difference of –2.56%). Serum Cystatin C is a much more accurate marker for estimating GFR in SCI, compared to serum Creatinine which overestimates GFR.\",\"PeriodicalId\":21976,\"journal\":{\"name\":\"Spinal cord\",\"volume\":\"62 6\",\"pages\":\"295-299\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2024-03-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Spinal cord\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.nature.com/articles/s41393-024-00973-y\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Spinal cord","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/s41393-024-00973-y","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

摘要

研究设计观察性队列。目标评估胱抑素 C 是否能准确估算运动能力受损的 SCI 患者的 GFR。研究在该人群中使用血清肌酐估算 GFR 是否会明显高估 GFR，从而导致不准确。方法招募符合纳入标准的 30 名 SCI 患者（ASIA A 和 B）。获取血清肌酐和血清胱抑素 C 值，并根据现有公式计算 eGFR。用布兰德-阿特曼图分析表明，以 24 小时尿肌酐为参考值，用血清胱抑素 C 估算的 eGFR 比血清肌酐更准确。结论与高估 GFR 的血清肌酸酐相比，血清胱抑素 C 是估算 SCI 患者 GFR 更为准确的指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Assessment of renal function in persons with motor complete spinal cord injury—cystatin C as an accurate single marker

查看原文本刊更多论文

Assessment of renal function in persons with motor complete spinal cord injury—cystatin C as an accurate single marker

Observational cohort. To show that Cystatin C is an accurate single marker to estimate GFR in motor complete persons with SCI. To assess if Cystatin C is an accurate for estimating GFR in persons with SCI with no preserved motor power. To study if use of Serum creatinine for estimation of GFR in this population significantly overestimates GFR, thereby inaccurate. Tertiary care hospital and Medical College, Vellore, South India. 30 persons with SCI (ASIA A and B) fulfilling the inclusion criteria were recruited. Serum Creatinine and Serum Cystatin C values were obtained, and eGFR was calculated based on available formulae. 24-h urine for urine creatinine clearance-based eGFR was used as a reference value. Analysis with a Bland-Atman plot showed that eGFR estimated with Serum Cystatin C was more accurate than Serum Creatinine, using 24-h urine creatinine as a reference value. eGFR using Serum Creatinine significantly overestimated GFR by over 50.6%. Estimated GFR using Serum Cystatin C showed a meager mean difference of 0.5% from the reference 24-h urine creatinine clearance (mean difference of –2.56%). Serum Cystatin C is a much more accurate marker for estimating GFR in SCI, compared to serum Creatinine which overestimates GFR.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Spinal cord 医学-临床神经学

CiteScore

4.50

自引率

9.10%

发文量

142

审稿时长

2 months

期刊介绍： Spinal Cord is a specialised, international journal that has been publishing spinal cord related manuscripts since 1963. It appears monthly, online and in print, and accepts contributions on spinal cord anatomy, physiology, management of injury and disease, and the quality of life and life circumstances of people with a spinal cord injury. Spinal Cord is multi-disciplinary and publishes contributions across the entire spectrum of research ranging from basic science to applied clinical research. It focuses on high quality original research, systematic reviews and narrative reviews. Spinal Cord''s sister journal Spinal Cord Series and Cases: Clinical Management in Spinal Cord Disorders publishes high quality case reports, small case series, pilot and retrospective studies perspectives, Pulse survey articles, Point-couterpoint articles, correspondences and book reviews. It specialises in material that addresses all aspects of life for persons with spinal cord injuries or disorders. For more information, please see the aims and scope of Spinal Cord Series and Cases.