从具有抗炎作用的油茶籽渣中分离和微生物转化茶苷元

IF 4 2区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE
Pingping SHEN , Xuewa JIANG , Jingling ZHANG , Jiayi WANG , Richa Raj , Guolong LI , Haixia GE , Weiwei WANG , Boyang YU , Jian ZHANG
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引用次数: 0

摘要

在当前的研究中,茶皂素被确定为油茶籽渣中的主要生物活性成分,经过精心提取和水解,得到了五种已知的苷元:16-O-tiglogycamelliagnin B(a)、山茶苷元 A(b)、16-O-angeloybarringtogenol C(c)、山茶苷元 E(d)、山茶苷元 F(e)。化合物 a 的后续生物转化促进了六种新型代谢物(a1-a6)的分离。利用病原体相关分子模式(PAMPs)和损伤相关分子模式分子(DAMPs)介导的细胞炎症模型评估了这些化合物的抗炎潜力。值得注意的是,化合物 b 和 a2 对脂多糖(LPS)和高迁移率基团框 1(HMGB1)诱导的炎症均有显著的抑制作用,其效果超过了标准抗炎剂卡贝诺龙。相反,化合物 d、a3 和 a6 选择性地针对内源性 HMGB1 诱导的炎症,显示出明显的特异性。这些结果凸显了油橄榄果籽衍生化合物的治疗前景,它们是治疗由感染和组织损伤引发的炎症性疾病的有效药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Isolation and microbial transformation of tea sapogenin from seed pomace of Camellia oleifera with anti-inflammatory effects

In the current study, tea saponin, identified as the primary bioactive constituent in seed pomace of Camellia oleifera Abel., was meticulously extracted and hydrolyzed to yield five known sapogenins: 16-O-tiglogycamelliagnin B (a), camelliagnin A (b), 16-O-angeloybarringtogenol C (c), theasapogenol E (d), theasapogenol F (e). Subsequent biotransformation of compound a facilitated the isolation of six novel metabolites (a1a6). The anti-inflammatory potential of these compounds was assessed using pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns molecules (DAMPs)-mediated cellular inflammation models. Notably, compounds b and a2 demonstrated significant inhibitory effects on both lipopolysaccharide (LPS) and high-mobility group box 1 (HMGB1)-induced inflammation, surpassing the efficacy of the standard anti-inflammatory agent, carbenoxolone. Conversely, compounds d, a3, and a6 selectivity targeted endogenous HMGB1-induced inflammation, showcasing a pronounced specificity. These results underscore the therapeutic promise of C. oleifera seed pomace-derived compounds as potent agents for the management of inflammatory diseases triggered by infections and tissue damage.

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来源期刊
Chinese Journal of Natural Medicines
Chinese Journal of Natural Medicines INTEGRATIVE & COMPLEMENTARY MEDICINE-PHARMACOLOGY & PHARMACY
CiteScore
7.50
自引率
4.30%
发文量
2235
期刊介绍: The Chinese Journal of Natural Medicines (CJNM), founded and sponsored in May 2003 by China Pharmaceutical University and the Chinese Pharmaceutical Association, is devoted to communication among pharmaceutical and medical scientists interested in the advancement of Traditional Chinese Medicines (TCM). CJNM publishes articles relating to a broad spectrum of bioactive natural products, leading compounds and medicines derived from Traditional Chinese Medicines (TCM). Topics covered by the journal are: Resources of Traditional Chinese Medicines; Interaction and complexity of prescription; Natural Products Chemistry (including structure modification, semi-and total synthesis, bio-transformation); Pharmacology of natural products and prescription (including pharmacokinetics and toxicology); Pharmaceutics and Analytical Methods of natural products.
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