激素和机械信号在乳腺形态动力学中的相互作用

IF 13 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2024-06-01 Epub Date: 2024-03-27 DOI:10.1016/j.tcb.2024.03.004

Alişya A Anlaş, Celeste M Nelson

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引用次数: 0

摘要

乳腺密度是一种公认的乳腺癌风险因素。在最近的一项研究中，Northey等人发现，组织僵硬度的相关增加会提高细胞外信号调节激酶（ERK）的活性，促进依赖孕酮受体的核因子κβ受体激活剂（RANK）信号传导。因此，硬度改变了激素信号的环境，增加了乳腺干细胞。这一机制为治疗乳腺癌提供了可能。

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Interplay between hormonal and mechanical signals in mammary morphodynamics.

Mammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.