重组蛇类抗蛇毒血清更接近临床。

IF 13.1 1区医学 Q1 IMMUNOLOGY

Trends in Immunology Pub Date : 2024-04-01 Epub Date: 2024-03-26 DOI:10.1016/j.it.2024.03.001

Andreas H Laustsen

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引用次数: 0

摘要

每年约有 100,000 名被蛇咬伤的受害者死于蛇毒，还有更多的人留下永久性后遗症。抗蛇毒血清问世已有 125 年之久，但亟待创新。Khalek 等人的一项新研究强调了广谱中和人类单克隆抗体 (mAbs)，可用于开发具有卓越治疗效果的重组抗蛇毒血清。

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Recombinant snake antivenoms get closer to the clinic.

Snakebite envenomings kill ~100 000 victims each year and leave many more with permanent sequelae. Antivenoms have been available for more than 125 years but are in need of innovation. A new study by Khalek et al. highlights broadly neutralizing human monoclonal antibodies (mAbs) that might be used to develop recombinant antivenoms with superior therapeutic benefits.

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来源期刊

Trends in Immunology 医学-免疫学

CiteScore

25.10

自引率

0.60%

发文量

130

审稿时长

6-12 weeks

期刊介绍： Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.