Seong Su Hong, Jae Yeon Lee, Yeon Woo Jeong, Ji Eun Lee, Yun-Hyeok Choi, Wonsik Jeong, Eun-Kyung Ahn, Chun Whan Choi, Il Ho Ahn, Joa Sub Oh
{"title":"Veratrum versicolor f. viride Nakai 气生部分的植物化学研究及其生物活性。","authors":"Seong Su Hong, Jae Yeon Lee, Yeon Woo Jeong, Ji Eun Lee, Yun-Hyeok Choi, Wonsik Jeong, Eun-Kyung Ahn, Chun Whan Choi, Il Ho Ahn, Joa Sub Oh","doi":"10.55730/1300-0527.3618","DOIUrl":null,"url":null,"abstract":"<p><p><i>Veratrum</i> spp. have traditionally been used in folk medicine to treat various pathologies. In this study, nine compounds, comprising one simple phenolic compound (<b>1</b>), three stilbenoids (<b>2</b>-<b>4</b>), and five flavonoids (<b>5</b>-<b>9</b>), were isolated from the aerial parts of <i>Veratrum versicolor</i> f. <i>viride</i> Nakai. The structures of these compounds were elucidated by spectroscopic analyses and comparison with reported data. Together, all reported compounds were isolated from <i>V. versicolor</i> f. <i>viride</i> for the first time in the study. Among them, two flavone aglycone tricetins (<b>7</b> and <b>9</b>) have never been isolated from the genus <i>Veratrum</i> or the family Melanthiaceae. The ethanol extract and isolated compounds were assessed for their inhibitory effects on elastase, tyrosinase, and melanin synthesis. Compounds <b>5</b> and <b>7</b> inhibited elastase (IC<sub>50</sub>: 292.25 ± 14.39 and 800.41 ± 5.86 μM, respectively), whereas compounds <b>2</b>-<b>5</b> inhibited tyrosinase with IC<sub>50</sub> values in the range of 6.42 ~ 51.19 μM, respectively. In addition, compounds <b>3</b>-<b>6</b> and <b>8</b> exhibited dose-dependent inhibition (70.4% ~ 91.0%) of melanogenesis at a concentration of 100 μM.</p>","PeriodicalId":23367,"journal":{"name":"Turkish Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10965189/pdf/","citationCount":"0","resultStr":"{\"title\":\"Phytochemical investigation on the aerial parts of <i>Veratrum versicolor</i> f. <i>viride</i> Nakai and their biological activities.\",\"authors\":\"Seong Su Hong, Jae Yeon Lee, Yeon Woo Jeong, Ji Eun Lee, Yun-Hyeok Choi, Wonsik Jeong, Eun-Kyung Ahn, Chun Whan Choi, Il Ho Ahn, Joa Sub Oh\",\"doi\":\"10.55730/1300-0527.3618\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Veratrum</i> spp. have traditionally been used in folk medicine to treat various pathologies. In this study, nine compounds, comprising one simple phenolic compound (<b>1</b>), three stilbenoids (<b>2</b>-<b>4</b>), and five flavonoids (<b>5</b>-<b>9</b>), were isolated from the aerial parts of <i>Veratrum versicolor</i> f. <i>viride</i> Nakai. The structures of these compounds were elucidated by spectroscopic analyses and comparison with reported data. Together, all reported compounds were isolated from <i>V. versicolor</i> f. <i>viride</i> for the first time in the study. Among them, two flavone aglycone tricetins (<b>7</b> and <b>9</b>) have never been isolated from the genus <i>Veratrum</i> or the family Melanthiaceae. The ethanol extract and isolated compounds were assessed for their inhibitory effects on elastase, tyrosinase, and melanin synthesis. Compounds <b>5</b> and <b>7</b> inhibited elastase (IC<sub>50</sub>: 292.25 ± 14.39 and 800.41 ± 5.86 μM, respectively), whereas compounds <b>2</b>-<b>5</b> inhibited tyrosinase with IC<sub>50</sub> values in the range of 6.42 ~ 51.19 μM, respectively. In addition, compounds <b>3</b>-<b>6</b> and <b>8</b> exhibited dose-dependent inhibition (70.4% ~ 91.0%) of melanogenesis at a concentration of 100 μM.</p>\",\"PeriodicalId\":23367,\"journal\":{\"name\":\"Turkish Journal of Chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2023-09-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10965189/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Turkish Journal of Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.55730/1300-0527.3618\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Turkish Journal of Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.55730/1300-0527.3618","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Phytochemical investigation on the aerial parts of Veratrum versicolor f. viride Nakai and their biological activities.
Veratrum spp. have traditionally been used in folk medicine to treat various pathologies. In this study, nine compounds, comprising one simple phenolic compound (1), three stilbenoids (2-4), and five flavonoids (5-9), were isolated from the aerial parts of Veratrum versicolor f. viride Nakai. The structures of these compounds were elucidated by spectroscopic analyses and comparison with reported data. Together, all reported compounds were isolated from V. versicolor f. viride for the first time in the study. Among them, two flavone aglycone tricetins (7 and 9) have never been isolated from the genus Veratrum or the family Melanthiaceae. The ethanol extract and isolated compounds were assessed for their inhibitory effects on elastase, tyrosinase, and melanin synthesis. Compounds 5 and 7 inhibited elastase (IC50: 292.25 ± 14.39 and 800.41 ± 5.86 μM, respectively), whereas compounds 2-5 inhibited tyrosinase with IC50 values in the range of 6.42 ~ 51.19 μM, respectively. In addition, compounds 3-6 and 8 exhibited dose-dependent inhibition (70.4% ~ 91.0%) of melanogenesis at a concentration of 100 μM.
期刊介绍：
The Turkish Journal of Chemistry is a bimonthly multidisciplinary journal published by the Scientific and Technological Research Council of Turkey (TÜBİTAK).
The journal is dedicated to dissemination of knowledge in all disciplines of chemistry (organic, inorganic, physical, polymeric, technical, theoretical and analytical chemistry) as well as research at the interface with other sciences especially in chemical engineering where molecular aspects are key to the findings.
The journal accepts English-language original manuscripts and contribution is open to researchers of all nationalities.
The journal publishes refereed original papers, reviews, letters to editor and issues devoted to special fields.
All manuscripts are peer-reviewed and electronic processing ensures accurate reproduction of text and data, plus publication times as short as possible.
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