设计和开发无创眼压估算器。

IF 1.6 4区 医学 Q3 OPHTHALMOLOGY
Siddharth K Karthikeyan, Swaminathan M Sundaram, Ramesh S Ve, Donson D Souza, Sayantan Biswas, Mayur U Shetty
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引用次数: 0

摘要

意义重大:眼压快照无法有效识别眼压峰值和波动,尤其是在睡眠期间。目的:我们旨在设计一种眼压估算器(OPE),它能在闭眼状态下可靠、准确地测量眼压:眼压估算器的工作原理是:眼球眼压升高所产生的外部压力通过可压缩隔膜传递到压力传感器,从而记录眼压。在模拟眼睑(隔膜)的橡胶手套上放置一个装有压力传感器的液袋,覆盖在去核山羊眼球的角膜上。压力控制装置与山羊尸体眼球相连,并通过回弹式眼压计进行验证。与通过视神经插管相比,通过下眼缘插管的眼球与使用回弹式眼压计记录的对照设置值的差异最小。眼压范围为 3 至 30 毫米汞柱,使用 OPE 记录的输出被放大并记录 10 分钟(n = 10 只眼睛)。我们对次数和诱导压力进行了分层随机化:结果:当测量眼压范围为 3 至 30 mmHg 时,所记录的测量结果呈线性。该设备具有极佳的可靠性(类内相关系数为 0.998)。重复性系数和变异系数分别为 4.24(3.60 至 4.87)和 8.61%(7.33 至 9.90)。在所有眼压范围内,诱导眼压与 OPE 之间的总体平均差值(± SD)为 0.22 ± 3.50(95% 置信区间,-0.35 至 0.79)mmHg:眼压估算器为在模拟闭眼状态下可靠、准确地测量眼压及其波动提供了一种很有前景的无创方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Design and development of a noninvasive ocular pressure estimator.

Significance: A snapshot intraocular pressure (IOP) is ineffective in identifying the IOP peak and fluctuation, especially during sleep. Because IOP variability plays a significant role in the progression of glaucoma, monitoring the IOP, especially during sleep, is essential to capture the dynamic nature of IOP.

Purpose: We aimed to design an ocular pressure estimator (OPE) that can reliably and accurately measure the IOP noninvasively over closed-eyelid condition.

Methods: Ocular pressure estimator works on the principle that the external pressure applied by raising the IOP of the eyeball is transmitted through a compressible septum to the pressure sensor, thus recording the IOP. A fluid-filled pouch with a pressure sensor was placed over a rubber glove mimicking the eyelid (septum), covering the cornea of enucleated goat eyeballs. A pressure-controlled setup was connected to a goat cadaver eye, which was validated by a rebound tonometer. Cannulation of eyeballs through the lower limbus had the least difference from the control setup values documented using rebound tonometer, compared with cannulation through the optic nerve. Intraocular pressures ranging from 3 to 30 mmHg was induced, and the outputs recorded using OPE were amplified and recorded for 10 minutes (n = 10 eyes). We stratified the randomization of the number of times and the induced pressures.

Results: The measurements recorded were found to be linear when measured against an IOP range of 3 to 30 mmHg. The device has excellent reliability (intraclass correlation coefficient, 0.998). The repeatability coefficient and coefficient of variations were 4.24 (3.60 to 4.87) and 8.61% (7.33 to 9.90), respectively. The overall mean difference ± SD between induced IOP and the OPE was 0.22 ± 3.50 (95% confidence interval, -0.35 to 0.79) mmHg across all IOP ranges.

Conclusions: Ocular pressure estimator offers a promising approach for reliably and accurately measuring IOP and its fluctuation noninvasively under a condition mimicking a closed eye.

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来源期刊
Optometry and Vision Science
Optometry and Vision Science 医学-眼科学
CiteScore
2.80
自引率
7.10%
发文量
210
审稿时长
3-6 weeks
期刊介绍: Optometry and Vision Science is the monthly peer-reviewed scientific publication of the American Academy of Optometry, publishing original research since 1924. Optometry and Vision Science is an internationally recognized source for education and information on current discoveries in optometry, physiological optics, vision science, and related fields. The journal considers original contributions that advance clinical practice, vision science, and public health. Authors should remember that the journal reaches readers worldwide and their submissions should be relevant and of interest to a broad audience. Topical priorities include, but are not limited to: clinical and laboratory research, evidence-based reviews, contact lenses, ocular growth and refractive error development, eye movements, visual function and perception, biology of the eye and ocular disease, epidemiology and public health, biomedical optics and instrumentation, novel and important clinical observations and treatments, and optometric education.
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