绵羊和山羊口服德拉克西布的处置动力学比较。

IF 1.5 4区 农林科学 Q3 PHARMACOLOGY & PHARMACY
Charbel Fadel, Beata Łebkowska-Wieruszewska, Andrzej Lisowski, Firas Serih, Amnart Poapolathep, Mario Giorgi
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引用次数: 0

摘要

本研究调查了选择性 COX-2 抑制剂德拉克昔布 (DX) 在绵羊和山羊中单次口服后的药代动力学 (PK)。DX已被批准用于狗,有望成为小反刍动物的替代非甾体抗炎药,特别是考虑到人们对腹腔溃疡的高度关注。该研究采用了口服DX的方法,剂量为150毫克/头(绵羊和山羊),在验证了高效液相色谱法和紫外检测器后测定了血浆浓度。通过非室分析评估了PK参数,包括最大血浆浓度(Cmax)、达到Cmax的时间(Tmax)、消除半衰期(t1/2)和曲线下面积(AUC)。结果显示,血浆中可检测到的 DX 达 48 小时,未观察到不良反应。绵羊和山羊的任何 PK 参数均无明显差异。值得注意的是,t1/2值相对较长,绵羊为16.66小时,山羊为22.86小时。尽管两个物种的药物暴露量相当,但每个物种的个体差异都很大,这表明应考虑到个体对 DX 治疗的反应差异,而不是特定物种的考虑因素。要全面评估 DX 在这些物种中的特性,还需要进行更多涉及药效学和多剂量研究的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparative disposition kinetics of oral deracoxib in sheep and goats

This study investigates the pharmacokinetics (PK) of deracoxib (DX), a selective COX-2 inhibitor, in sheep and goats following a single oral dose. DX, approved for dogs, holds potential as an alternative NSAID in small ruminants, particularly in light of heightened concern regarding abomasal ulceration. The study employed an oral administration of DX at a dose of 150 mg/head (sheep and goats), and plasma concentrations were determined after validating a high-performance liquid chromatography method, coupled to a UV detector. The PK parameters, including maximum plasma concentration (C max), time to reach C max (T max), elimination half-life (t 1/2), and area under the curve (AUC), were evaluated through non-compartmental analysis. Results showed detectable DX in plasma up to 48 h, with no observed adverse effects. No significant differences in any PK parameters were noted between sheep and goats. Notably, t 1/2 values were relatively long, at 16.66 h for sheep and 22.86 h for goats. Despite the fact that both species exhibited comparable drug exposure, high individual variability was noted within each species, suggesting to take into account individual variations in response to DX treatment, rather than species-specific considerations. Additional research involving pharmacodynamics and multiple-dose studies is warranted to comprehensively assess the profile of DX in these species.

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来源期刊
CiteScore
3.10
自引率
15.40%
发文量
69
审稿时长
8-16 weeks
期刊介绍: The Journal of Veterinary Pharmacology and Therapeutics (JVPT) is an international journal devoted to the publication of scientific papers in the basic and clinical aspects of veterinary pharmacology and toxicology, whether the study is in vitro, in vivo, ex vivo or in silico. The Journal is a forum for recent scientific information and developments in the discipline of veterinary pharmacology, including toxicology and therapeutics. Studies that are entirely in vitro will not be considered within the scope of JVPT unless the study has direct relevance to the use of the drug (including toxicants and feed additives) in veterinary species, or that it can be clearly demonstrated that a similar outcome would be expected in vivo. These studies should consider approved or widely used veterinary drugs and/or drugs with broad applicability to veterinary species.
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