捷克男性接触苯并三唑和苯并噻唑的情况及其与肝功能生物标志物、血清脂质和氧化应激的关系

IF 2.6 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Nina Pálešová, Lucie Bláhová, Tomáš Janoš, Katarína Řiháčková, Aleš Pindur, Ludmila Šebejová, Pavel Čupr
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引用次数: 0

摘要

导言:苯并三唑和苯并噻唑(BTs)是高产量化学品,也是广泛分布的新兴污染物,具有潜在的健康风险。然而,有关人类暴露于 BTs 和相关健康结果的信息非常有限:方法:165 名参与者(包括 110 名消防员)提供了尿液和血液样本,用于量化尿液中 8 种 BTs(高效液相色谱-串联质谱法)、4 种肝酶、胆固醇、低密度脂蛋白和 8- 羟基-2'-脱氧鸟苷的水平。线性回归用于评估人口特征与肝功能生物标志物、血清脂质和氧化应激之间的关联。回归模型根据潜在的混杂变量进行了调整,并采用了误发现率程序以考虑多重性:结果:BTs 的范围从未被发现到 46.8 纳克/毫升不等。2-羟基苯并噻唑是最主要的化合物(检测频率为 83%;中位数为 1.95 纳克/毫升)。人体样本中首次检测到 1-甲基苯并三唑(1M-BTR),检测频率为 77%,中位数为 1.75 纳克/毫升。与非消防员相比,职业消防员尿液中的 1M-BTR 含量较低。尿液中的 1M-BTR 与γ-谷氨酰转移酶水平相关(β = - 17.54%; 95% CI: - 26.127, - 7.962):这是首次调查中欧地区 BT 暴露情况的研究,其中包括可能暴露于 BT 的消防员。研究结果表明,研究人群中 BT 的发病率很高,1M-BTR 作为一种新的生物标志物对暴露具有相关性,而且迫切需要进一步研究相关的不良健康后果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Exposure to benzotriazoles and benzothiazoles in Czech male population and its associations with biomarkers of liver function, serum lipids and oxidative stress.

Exposure to benzotriazoles and benzothiazoles in Czech male population and its associations with biomarkers of liver function, serum lipids and oxidative stress.

Introduction: Benzotriazoles and benzothiazoles (BTs) are high-production volume chemicals as well as widely distributed emerging pollutants with potential health risk. However, information about human exposure to BTs and associated health outcomes is limited.

Objective: We aimed to characterise exposure to BTs among Czech men, including possible occupational exposure among firefighters, its predictors, and its associations with liver function, serum lipids and oxidative stress.

Methods: 165 participants (including 110 firefighters) provided urine and blood samples that were used to quantify the urinary levels of 8 BTs (high-performance liquid chromatography-tandem mass spectrometry), and 4 liver enzymes, cholesterol, low-density lipoprotein, and 8-hydroxy-2'-deoxyguanosine. Linear regression was used to assess associations with population characteristics and biomarkers of liver function, serum lipids and oxidative stress. Regression models were adjusted for potential confounding variables and false discovery rate procedure was applied to account for multiplicity.

Results: The BTs ranged from undetected up to 46.8 ng/mL. 2-hydroxy-benzothiazole was the most predominant compound (detection frequency 83%; median 1.95 ng/mL). 1-methyl-benzotriazole (1M-BTR) was measured in human samples for the first time, with a detection frequency 77% and median 1.75 ng/mL. Professional firefighters had lower urinary 1M-BTR compared to non-firefighters. Urinary 1M-BTR was associated with levels of γ-glutamyl transferase (β = - 17.54%; 95% CI: - 26.127, - 7.962).

Conclusion: This is the first study to investigate BT exposure in Central Europe, including potentially exposed firefighters. The findings showed a high prevalence of BTs in the study population, the relevance of 1M-BTR as a new biomarker of exposure, and an urgent need for further research into associated adverse health outcomes.

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来源期刊
International Archives of Occupational and Environmental Health
International Archives of Occupational and Environmental Health 医学-公共卫生、环境卫生与职业卫生
CiteScore
5.60
自引率
6.70%
发文量
127
审稿时长
3 months
期刊介绍: International Archives of Occupational and Environmental Health publishes Editorials, Review Articles, Original Articles, and Letters to the Editor. It welcomes any manuscripts dealing with occupational or ambient environmental problems, with a special interest in research at the interface of occupational health and clinical medicine. The scope ranges from Biological Monitoring to Dermatology, from Fibers and Dust to Human Toxicology, from Nanomaterials and Ultra-fine Dust to Night- and Shift Work, from Psycho-mental Distress and Burnout to Vibrations. A complete list of topics can be found on the right-hand side under For authors and editors. In addition, all papers should be based on present-day standards and relate to: -Clinical and epidemiological studies on morbidity and mortality -Clinical epidemiological studies on the parameters relevant to the estimation of health risks -Human experimental studies on environmental health effects. Animal experiments are only acceptable if relevant to pathogenic aspects. -Methods for studying the topics mentioned above.
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