{"title":"微波消融参数对不同癌组织套管定位的影响:数值研究。","authors":"Vellavalapalli Satish, Ramjee Repaka","doi":"10.1080/15368378.2024.2333802","DOIUrl":null,"url":null,"abstract":"<p><p>The present study analyzed the microwave ablation of cancerous tumors located in six major cancer-prone organs and estimated the significance of input power and treatment time parameters in the apt positioning of the trocar into the tissue during microwave ablation. The present study has considered a three-dimensional two-compartment tumour-embedded tissue model. FEA based COMSOL Multiphysics software with inbuilt bioheat transfer, electromagnetic waves, heat transfer in solids and fluids, and laminar flow physics has been used to obtain the numerical results. Based on the mortality rates caused by cancer, the present study has considered six major organs affected by cancer, viz. lung, breast, stomach/gastric, liver, liver (with colon metastasis), and kidney for MWA analysis. The input power (100 W) and ablation times (4 minutes) with apt and inapt positioning of the trocar have been considered to compare the ablation volume of various cancerous tissues. The present study addresses one of the major problems clinicians face, i.e. the proper placement of the trocar due to poor imaging techniques and human error, resulting in incomplete tumor ablation and increased surgical procedures. The highest values of the ablation region have been observed for the liver, colon metastatic liver and breast cancerous tissues compared with other organs at the same operating conditions.</p>","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"125-134"},"PeriodicalIF":1.5000,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The influence of microwave ablation parameters on the positioning of trocar in different cancerous tissues: a numerical study.\",\"authors\":\"Vellavalapalli Satish, Ramjee Repaka\",\"doi\":\"10.1080/15368378.2024.2333802\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The present study analyzed the microwave ablation of cancerous tumors located in six major cancer-prone organs and estimated the significance of input power and treatment time parameters in the apt positioning of the trocar into the tissue during microwave ablation. The present study has considered a three-dimensional two-compartment tumour-embedded tissue model. FEA based COMSOL Multiphysics software with inbuilt bioheat transfer, electromagnetic waves, heat transfer in solids and fluids, and laminar flow physics has been used to obtain the numerical results. Based on the mortality rates caused by cancer, the present study has considered six major organs affected by cancer, viz. lung, breast, stomach/gastric, liver, liver (with colon metastasis), and kidney for MWA analysis. The input power (100 W) and ablation times (4 minutes) with apt and inapt positioning of the trocar have been considered to compare the ablation volume of various cancerous tissues. The present study addresses one of the major problems clinicians face, i.e. the proper placement of the trocar due to poor imaging techniques and human error, resulting in incomplete tumor ablation and increased surgical procedures. The highest values of the ablation region have been observed for the liver, colon metastatic liver and breast cancerous tissues compared with other organs at the same operating conditions.</p>\",\"PeriodicalId\":50544,\"journal\":{\"name\":\"Electromagnetic Biology and Medicine\",\"volume\":\" \",\"pages\":\"125-134\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2024-04-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Electromagnetic Biology and Medicine\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1080/15368378.2024.2333802\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/3/27 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Electromagnetic Biology and Medicine","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1080/15368378.2024.2333802","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/3/27 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"BIOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
本研究分析了微波消融六大癌症易发器官中的癌症肿瘤,并估算了输入功率和治疗时间参数对微波消融过程中套管在组织中准确定位的重要性。本研究考虑了三维两室肿瘤嵌入组织模型。为获得数值结果,使用了基于有限元分析的 COMSOL Multiphysics 软件,该软件内置生物传热、电磁波、固体和流体中的传热以及层流物理学。根据癌症造成的死亡率,本研究考虑了受癌症影响的六个主要器官,即肺、乳腺、胃/胃、肝脏、肝脏(结肠转移)和肾脏进行 MWA 分析。输入功率(100 W)和消融时间(4 分钟)以及套管的适当和不适当定位都被考虑在内,以比较各种癌症组织的消融量。本研究解决了临床医生面临的主要问题之一,即由于成像技术不佳和人为失误造成的套管针位置不当,从而导致肿瘤消融不完全和手术程序增加。在相同的操作条件下,与其他器官相比,肝脏、结肠转移性肝脏和乳腺癌组织的消融区域值最高。
The influence of microwave ablation parameters on the positioning of trocar in different cancerous tissues: a numerical study.
The present study analyzed the microwave ablation of cancerous tumors located in six major cancer-prone organs and estimated the significance of input power and treatment time parameters in the apt positioning of the trocar into the tissue during microwave ablation. The present study has considered a three-dimensional two-compartment tumour-embedded tissue model. FEA based COMSOL Multiphysics software with inbuilt bioheat transfer, electromagnetic waves, heat transfer in solids and fluids, and laminar flow physics has been used to obtain the numerical results. Based on the mortality rates caused by cancer, the present study has considered six major organs affected by cancer, viz. lung, breast, stomach/gastric, liver, liver (with colon metastasis), and kidney for MWA analysis. The input power (100 W) and ablation times (4 minutes) with apt and inapt positioning of the trocar have been considered to compare the ablation volume of various cancerous tissues. The present study addresses one of the major problems clinicians face, i.e. the proper placement of the trocar due to poor imaging techniques and human error, resulting in incomplete tumor ablation and increased surgical procedures. The highest values of the ablation region have been observed for the liver, colon metastatic liver and breast cancerous tissues compared with other organs at the same operating conditions.
期刊介绍:
Aims & Scope: Electromagnetic Biology and Medicine, publishes peer-reviewed research articles on the biological effects and medical applications of non-ionizing electromagnetic fields (from extremely-low frequency to radiofrequency). Topic examples include in vitro and in vivo studies, epidemiological investigation, mechanism and mode of interaction between non-ionizing electromagnetic fields and biological systems. In addition to publishing original articles, the journal also publishes meeting summaries and reports, and reviews on selected topics.