COVID-19 中的结缔组织疾病：对 "结缔组织疾病患者由于血管脆弱和伤口愈合缓慢，可能特别容易受到长 COVID 所特有的内皮损伤 "的答复。

IF 9.2 1区医学 Q1 PERIPHERAL VASCULAR DISEASE

Angiogenesis Pub Date : 2024-03-26 DOI:10.1007/s10456-024-09915-x

Xiaoming Wu, Valerie A. Novakovic, Jialan Shi

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引用次数: 0

摘要

结缔组织是其他组织和器官的框架，支持它们的功能，保护它们免受有害因素的影响，并帮助修复。在 COVID-19 中，受损的内皮细胞（EC）、内皮通透性增加和血栓是结缔组织病变的原因。即使在康复后，对内皮细胞和结缔组织的损伤依然存在，导致 COVID 长期存在。患有结缔组织疾病的人很容易出现严重的 COVID-19 和长时间的 COVID 症状。建议这些患者至少接种三剂疫苗，在急性 COVID-19 期间及早进行预防性抗血栓治疗，并在出现长期 COVID 时坚持预防性抗凝治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Connective tissue disorders in COVID-19: Reply to “People with a connective tissue disorder may be especially vulnerable to the endothelial damage that characterizes long COVID due to the fragility of their vasculature and slow wound healing”

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Connective tissue serves as a framework for other tissues and organs, supporting their functions, shielding them from harmful factors, and aiding repair. In COVID-19, damaged endothelial cells (ECs), increased endothelial permeability, and thrombi contribute to the connective tissue disorders. Even post-recovery, the damage to ECs and connective tissues persists, resulting in long COVID. Individuals with connective tissue disorders are prone to developing severe COVID-19 and experiencing long COVID symptoms. It is advised that these patients receive at least three vaccine doses, undergo early prophylactic antithrombotic therapy during acute COVID-19, and maintain prophylactic anticoagulant treatment in cases of long COVID.

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来源期刊

Angiogenesis PERIPHERAL VASCULAR DISEASE-

CiteScore

21.90

自引率

8.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Angiogenesis, a renowned international journal, seeks to publish high-quality original articles and reviews on the cellular and molecular mechanisms governing angiogenesis in both normal and pathological conditions. By serving as a primary platform for swift communication within the field of angiogenesis research, this multidisciplinary journal showcases pioneering experimental studies utilizing molecular techniques, in vitro methods, animal models, and clinical investigations into angiogenic diseases. Furthermore, Angiogenesis sheds light on cutting-edge therapeutic strategies for promoting or inhibiting angiogenesis, while also highlighting fresh markers and techniques for disease diagnosis and prognosis.