HIV/HBV 合并感染：了解复杂的相互作用及其对自发性 HBV 清除、慢性肝损伤、肝硬化和肝细胞癌的影响。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-01 DOI:10.24875/AIDSRev.23000019

Jingwen Xiao, Yongzheng Zhang, Jia Wu, Xinping -Chen, Wei Zou

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引用次数: 0

摘要

与艾滋病病毒或乙型肝炎病毒（HBV）单一感染者相比，艾滋病病毒/乙型肝炎病毒双重感染者自发清除 HBV 的几率更低，发生慢性肝损伤的风险更大，发展为肝硬化和肝细胞癌的速度更快。本手稿试图全面回顾当前 HIV/HBV 合并感染的研究现状，重点关注这两种病毒之间错综复杂的相互作用。我们的综述将有助于理解 HIV/HBV 合并感染的疾病动力学，并对设计公共卫生策略具有重要意义。

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HIV/HBV coinfection: understanding the complex interactions and their impact on spontaneous HBV clearance, chronic liver damage, cirrhosis, and hepatocellular carcinoma.

Compared to either HIV or hepatitis B virus (HBV) monoinfected individuals, HIV/HBV-coinfected individuals have a decreased probability of spontaneous HBV clearance and a greater risk of developing chronic liver damage and a faster progression to cirrhosis and hepatocellular carcinoma. This manuscript attempts to provide a comprehensive review of the landscape of current HIV/HBV coinfection research with a focus on the intricate interactions between these two viruses. Our review will help understand the disease dynamics of HIV/HBV coinfection and has important implications for designing public health strategies.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.