血小板中神经氨酸酶的去酰化作用,死亡之吻还是苦乐参半?

IF 3.1 3区 医学 Q2 HEMATOLOGY
Current Opinion in Hematology Pub Date : 2025-01-01 Epub Date: 2024-08-30 DOI:10.1097/MOH.0000000000000815
Nora Butta, Dianne E van der Wal
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引用次数: 0

摘要

综述的目的:由神经氨酸酶造成的表面硅烷基化被称为 "脱硅烷基化"。血小板在细菌或病毒感染、储存、衰老、各种突变、血小板自身抗体、止血和剪切应力等情况下都会发生脱ialylation。在这篇综述中,将介绍有关不同硅氨酰基封端聚糖结构的最新文献,以及遗传性聚糖紊乱和外部神经氨酸酶诱导的血小板去硅氨酰化:最新发现:神经氨酸酶从血小板细胞内贮存释放并转运至血小板表面。除清除外,神经氨酸酶造成的表面ialic酸损失("去ialylation")会影响血小板的信号传导,包括配体结合及其促凝功能。在感染、各种突变、血小板自身抗体存在的情况下,血小板也会发生脱ialylation。摘要:由于血小板脱ialylation发生在各种健康和病理情况下,因此测量脱ialylation可能是一种新的诊断工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Desialylation by neuraminidases in platelets, kiss of death or bittersweet?

Purpose of review: Loss of surface sialic acid by neuraminidases is known as 'desialylation'. Platelets are desialylated in bacterial or viral infections, during storage, senescence, various mutations, platelet auto antibodies, hemostasis and shear stress. In this review the recent literature on the different sialic acid capped glycan structures will be covered as well as platelet desialylation in inherited glycan disorders and induced by external neuraminidases.

Recent findings: Neuraminidases are released from platelet intracellular stores and translocated to the platelet surface. Apart from clearance, loss of surface sialic acid by neuraminidases ('desialylation') affects platelet signaling including ligand binding and their procoagulant function. Platelets are also desialylated in infections, various mutations, presence of platelet auto antibodies.

Summary: Since platelet desialylation occurs in various healthy and pathological conditions, measuring desialylation might be a new diagnostic tool.

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来源期刊
CiteScore
6.60
自引率
3.10%
发文量
78
审稿时长
6-12 weeks
期刊介绍: ​​​​​​​​Current Opinion in Hematology is an easy-to-digest bimonthly journal covering the most interesting and important advances in the field of hematology. Its hand-picked selection of editors ensure the highest quality selection of unbiased review articles on themes from nine key subject areas, including myeloid biology, Vascular biology, hematopoiesis and erythroid system and its diseases.
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