使用 CORVIS ST 设备分析中东人种不同近视度数的角膜生物力学特征

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-03-01 DOI:10.2147/opth.s451328

Esraa El-Mayah, Ahmed Albalkini, Omar Barrada

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引用次数: 0

摘要

目的：使用 CORVIS-ST 设备分析近视患者的角膜生物力学特性。研究方法：这项前瞻性横断面研究包括近视患者。我们的研究包括 154 名近视患者的 154 只眼睛，他们的年龄在 18 岁至 40 岁之间，屈光度数至少稳定在 2 年以上。研究人员使用 Pentacam HR 设备进行了全面的眼科检查和角膜断层扫描。使用 CORVIS-ST 设备评估了轻度、中度、重度和极度近视组的角膜生物力学参数。结果：在DA比率（p=0.033）、SP-A（p=0.009）、CBI（p=0.041）、SSI（p=0.000）和峰距（p=0.032）方面观察到了统计学上的显著差异。在与 Corvis ST 不同生物力学变量的相关性分析中，发现 SE 与 DA ratio（r=-0.191，p=0.018）、SP-A（r=0.199，p=0.013）和 SSI（r=-0.336，p=0.000）相关，而在多元回归分析中，发现 SE 与 SSI 和峰值距离独立相关（分别为 p=0.036、0.038），而近视度数与 SP-A 独立相关（p=0.034）。结论SSI、峰距和SP-A与SE和近视度数独立相关，证实了近视度数越高的眼睛变形越大、抗应力能力越弱的假设。

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Characterization of Corneal Biomechanics Using CORVIS ST Device in Different Grades of Myopia in a Sample of Middle Eastern Ethnicity

Purpose: To characterize corneal biomechanical properties using the CORVIS-ST device in myopic individuals. Methods: This prospective cross-sectional study included patients with myopia. Our study included 154 eyes of 154 myopic patients aged between 18 and 40 years, with stable refraction for at least 2 years. A full ophthalmological examination and corneal tomography were performed using a Pentacam HR device. Corneal biomechanical parameters were assessed using the CORVIS-ST device in mild, moderate, severe, and extreme myopia groups. Results: Statistically significant differences were observed in the DA ratio (p = 0.033), SP-A (p=0.009), CBI (p=0.041), SSI (p=0.000), and Peak distance (p = 0.032). In correlation with different Corvis ST biomechanical variables, SE was found to be correlated with DA ratio(r=−0.191, p=0.018), SP-A(r=0.199, p=0.013) and SSI(r=−0.336, p=0.000), while in multiple regression analysis, SE was found to be independently correlated with SSI and peak distance(p=0.036,0.038 respectively) while the grade of myopia was found to be independently correlated with SP-A(p=0.034). Conclusion: SSI, Peak distance, and SP-A were independently related to SE and myopia grade, confirming the hypothesis that eyes with higher myopia are more deformable and less stress resistant.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.