Deanne K. Thompson , Claire E. Kelly , Thijs Dhollander , Evelyne Muggli , Stephen Hearps , Sharon Lewis , Thi-Nhu-Ngoc Nguyen , Alicia Spittle , Elizabeth J. Elliott , Anthony Penington , Jane Halliday , Peter J. Anderson
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Magnetic resonance imaging was undertaken for 143 children aged 6 to 8 years with PAE during trimester 1 only (n = 44), PAE throughout gestation (n = 58), and no PAE (n = 41). <em>T<sub>1</sub></em>-weighted images were processed using FreeSurfer, obtaining brain volume, area, and thickness of 34 cortical regions per hemisphere. Fibre density (FD), fibre cross-section (FC) and fibre density and cross-section (FDC) metrics were computed for diffusion images. Brain measures were compared between PAE groups adjusted for age and sex, then additionally for intracranial volume.</p></div><div><h3>Results</h3><p>After adjustments, the right caudal anterior cingulate cortex volume (<em>p</em><sub>FDR</sub> = 0.045) and area (<em>p</em><sub>FDR</sub> = 0.008), and right cingulum tract cross-sectional area (p<sub>FWE</sub> < 0.05) were smaller in children exposed to alcohol throughout gestation compared with no PAE.</p></div><div><h3>Conclusion</h3><p>This study reports a relationship between low-moderate PAE throughout gestation and cingulate cortex and cingulum tract alterations, suggesting a teratogenic vulnerability. Further investigation is warranted.</p></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213158224000342/pdfft?md5=5577d6a07bcc6ec27a7102de4be0170e&pid=1-s2.0-S2213158224000342-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Associations between low-moderate prenatal alcohol exposure and brain development in childhood\",\"authors\":\"Deanne K. Thompson , Claire E. Kelly , Thijs Dhollander , Evelyne Muggli , Stephen Hearps , Sharon Lewis , Thi-Nhu-Ngoc Nguyen , Alicia Spittle , Elizabeth J. Elliott , Anthony Penington , Jane Halliday , Peter J. Anderson\",\"doi\":\"10.1016/j.nicl.2024.103595\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>The effects of low-moderate prenatal alcohol exposure (PAE) on brain development have been infrequently studied.</p></div><div><h3>Aim</h3><p>To compare cortical and white matter structure between children aged 6 to 8 years with low-moderate PAE in trimester 1 only, low-moderate PAE throughout gestation, or no PAE.</p></div><div><h3>Methods</h3><p>Women reported quantity and frequency of alcohol consumption before and during pregnancy. Magnetic resonance imaging was undertaken for 143 children aged 6 to 8 years with PAE during trimester 1 only (n = 44), PAE throughout gestation (n = 58), and no PAE (n = 41). <em>T<sub>1</sub></em>-weighted images were processed using FreeSurfer, obtaining brain volume, area, and thickness of 34 cortical regions per hemisphere. Fibre density (FD), fibre cross-section (FC) and fibre density and cross-section (FDC) metrics were computed for diffusion images. Brain measures were compared between PAE groups adjusted for age and sex, then additionally for intracranial volume.</p></div><div><h3>Results</h3><p>After adjustments, the right caudal anterior cingulate cortex volume (<em>p</em><sub>FDR</sub> = 0.045) and area (<em>p</em><sub>FDR</sub> = 0.008), and right cingulum tract cross-sectional area (p<sub>FWE</sub> < 0.05) were smaller in children exposed to alcohol throughout gestation compared with no PAE.</p></div><div><h3>Conclusion</h3><p>This study reports a relationship between low-moderate PAE throughout gestation and cingulate cortex and cingulum tract alterations, suggesting a teratogenic vulnerability. 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Associations between low-moderate prenatal alcohol exposure and brain development in childhood
Background
The effects of low-moderate prenatal alcohol exposure (PAE) on brain development have been infrequently studied.
Aim
To compare cortical and white matter structure between children aged 6 to 8 years with low-moderate PAE in trimester 1 only, low-moderate PAE throughout gestation, or no PAE.
Methods
Women reported quantity and frequency of alcohol consumption before and during pregnancy. Magnetic resonance imaging was undertaken for 143 children aged 6 to 8 years with PAE during trimester 1 only (n = 44), PAE throughout gestation (n = 58), and no PAE (n = 41). T1-weighted images were processed using FreeSurfer, obtaining brain volume, area, and thickness of 34 cortical regions per hemisphere. Fibre density (FD), fibre cross-section (FC) and fibre density and cross-section (FDC) metrics were computed for diffusion images. Brain measures were compared between PAE groups adjusted for age and sex, then additionally for intracranial volume.
Results
After adjustments, the right caudal anterior cingulate cortex volume (pFDR = 0.045) and area (pFDR = 0.008), and right cingulum tract cross-sectional area (pFWE < 0.05) were smaller in children exposed to alcohol throughout gestation compared with no PAE.
Conclusion
This study reports a relationship between low-moderate PAE throughout gestation and cingulate cortex and cingulum tract alterations, suggesting a teratogenic vulnerability. Further investigation is warranted.
期刊介绍：
NeuroImage: Clinical, a journal of diseases, disorders and syndromes involving the Nervous System, provides a vehicle for communicating important advances in the study of abnormal structure-function relationships of the human nervous system based on imaging.
The focus of NeuroImage: Clinical is on defining changes to the brain associated with primary neurologic and psychiatric diseases and disorders of the nervous system as well as behavioral syndromes and developmental conditions. The main criterion for judging papers is the extent of scientific advancement in the understanding of the pathophysiologic mechanisms of diseases and disorders, in identification of functional models that link clinical signs and symptoms with brain function and in the creation of image based tools applicable to a broad range of clinical needs including diagnosis, monitoring and tracking of illness, predicting therapeutic response and development of new treatments. Papers dealing with structure and function in animal models will also be considered if they reveal mechanisms that can be readily translated to human conditions.
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