脑静脉损伤和脑静脉窦血栓形成

IF 1.3 Q4 CLINICAL NEUROLOGY
Jiaqi Wang , Anatol Manaenko , Qin Hu , Xiaohua Zhang
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引用次数: 0

摘要

脑静脉负责脑组织间液(ISF)的外流引流。在各种神经系统疾病中,脑静脉引流的重要性都得到了强调。静脉外流受损可能导致脑水肿、血脑屏障(BBB)破坏、炎症反应和出血性并发症。随着成像技术的发展,提出了几种基于成像的静脉评估体征。针对脑静脉引流的疗法已在临床上显示出对脑静脉窦血栓形成(CVST)有益的结果,但还需要对细胞和分子水平有更深入的了解。在此,我们回顾了脑静脉引流受损后的病理变化,总结了基于图像评估的进展,探讨了潜在的分子机制,并讨论了以静脉引流为重点的疗法。更好地了解脑静脉引流及其内在机制将促进 CVST 的药物开发和临床治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cerebral venous impairment and cerebral venous sinus thrombosis

Cerebral veins are responsible for the outflow drainage of brain interstitial fluid (ISF). The importance of cerebral venous drainage has been emphasized in various neurological diseases. Impaired venous outflow may lead to brain edema, blood–brain barrier (BBB) disruption, inflammatory responses and hemorrhagic complications. With the development of imaging technologies, several imaging-based signs for venous assessment are proposed. Therapies targeting cerebral venous drainage have shown beneficial outcomes in cerebral venous sinus thrombosis (CVST) in clinic, however more insight into the cellular and molecular level should be elucidated. Here we review the pathological changes following cerebral venous drainage impairment, summary the advances in image-based evaluation, address the potential molecular mechanisms, and discuss venous drainage-focused therapies. A better understanding of cerebral venous drainage and its underlying mechanism will promote the pharmacological development and clinical management of CVST.

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来源期刊
Brain Hemorrhages
Brain Hemorrhages Medicine-Surgery
CiteScore
2.90
自引率
0.00%
发文量
52
审稿时长
22 days
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