Li Yun Teng , Chun Yuan Hsiao , Ken Peng Weng , Chia Ching Chen , Sen Wei Tsai , Ko Long Lin
{"title":"法洛氏四联症修复患者心肺功能和心脏超声检查的长期随访","authors":"Li Yun Teng , Chun Yuan Hsiao , Ken Peng Weng , Chia Ching Chen , Sen Wei Tsai , Ko Long Lin","doi":"10.1016/j.ppedcard.2024.101724","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Tetralogy of Fallot (TOF) is one of the most common cyanotic congenital heart defects and typically requires intracardiac repair to correct cardiac anomalies. Postoperative TOF patients have compromised exercise capacity, which tends to decline over time. We assessed cardiopulmonary function using serial exercise testing and echocardiographic findings from childhood to adolescence in patients with repaired TOF.</p></div><div><h3>Methods</h3><p>This was a retrospective study. We recruited children with TOF who underwent at least two treadmill cardiopulmonary exercise tests (CPET) (with >1-year interval between the tests) between 2005 and 2022. Serial echocardiography results were evaluated to compare long-term changes in ejection fraction and pulmonary arterial pulse wave velocity. Healthy controls who underwent serial CPETs with intervals >1 year were also recruited.</p></div><div><h3>Results</h3><p>A total of 86 participants and 86 age-, sex-, and body mass index-matched healthy peers were identified. Significant decreases were observed in the CPET parameters between the initial and final CPETs, including peak VO<sub>2</sub>% (<em>p</em> < 0.001), peak MET (<em>p</em> = 0.027), peak heart rate (<em>p</em> = 0.009), and MET at AT (<em>p</em> = 0.001). In comparison to the control group, the patient group exhibited inferior aerobic capacity in the initial CPET, characterized by smaller peak MET (<em>p</em> = 0.049), peak VO<sub>2</sub> (<em>p</em> = 0.001), and peak VO<sub>2</sub>% (<em>p</em> < 0.001). Furthermore, a notable decline in exercise capacity was noted in the patient group during the follow-up. No significant differences were observed between the serial ejection fraction and pulmonary arterial pulse wave velocity.</p></div><div><h3>Conclusions</h3><p>Patients with repaired TOF had inferior exercise capacities to their healthy peers, and the peak exercise load capacities tended to decline over time. However, they were safe to engage in exercise training since the CPET results exceeded the standard for moderate-to-vigorous physical activity.</p></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":null,"pages":null},"PeriodicalIF":0.6000,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Long-term follow-up of cardiopulmonary function and cardioechographic examinations in patients with repaired tetralogy of Fallot\",\"authors\":\"Li Yun Teng , Chun Yuan Hsiao , Ken Peng Weng , Chia Ching Chen , Sen Wei Tsai , Ko Long Lin\",\"doi\":\"10.1016/j.ppedcard.2024.101724\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Tetralogy of Fallot (TOF) is one of the most common cyanotic congenital heart defects and typically requires intracardiac repair to correct cardiac anomalies. Postoperative TOF patients have compromised exercise capacity, which tends to decline over time. We assessed cardiopulmonary function using serial exercise testing and echocardiographic findings from childhood to adolescence in patients with repaired TOF.</p></div><div><h3>Methods</h3><p>This was a retrospective study. We recruited children with TOF who underwent at least two treadmill cardiopulmonary exercise tests (CPET) (with >1-year interval between the tests) between 2005 and 2022. Serial echocardiography results were evaluated to compare long-term changes in ejection fraction and pulmonary arterial pulse wave velocity. Healthy controls who underwent serial CPETs with intervals >1 year were also recruited.</p></div><div><h3>Results</h3><p>A total of 86 participants and 86 age-, sex-, and body mass index-matched healthy peers were identified. Significant decreases were observed in the CPET parameters between the initial and final CPETs, including peak VO<sub>2</sub>% (<em>p</em> < 0.001), peak MET (<em>p</em> = 0.027), peak heart rate (<em>p</em> = 0.009), and MET at AT (<em>p</em> = 0.001). In comparison to the control group, the patient group exhibited inferior aerobic capacity in the initial CPET, characterized by smaller peak MET (<em>p</em> = 0.049), peak VO<sub>2</sub> (<em>p</em> = 0.001), and peak VO<sub>2</sub>% (<em>p</em> < 0.001). Furthermore, a notable decline in exercise capacity was noted in the patient group during the follow-up. No significant differences were observed between the serial ejection fraction and pulmonary arterial pulse wave velocity.</p></div><div><h3>Conclusions</h3><p>Patients with repaired TOF had inferior exercise capacities to their healthy peers, and the peak exercise load capacities tended to decline over time. However, they were safe to engage in exercise training since the CPET results exceeded the standard for moderate-to-vigorous physical activity.</p></div>\",\"PeriodicalId\":46028,\"journal\":{\"name\":\"PROGRESS IN PEDIATRIC CARDIOLOGY\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2024-03-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"PROGRESS IN PEDIATRIC CARDIOLOGY\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1058981324000225\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"PROGRESS IN PEDIATRIC CARDIOLOGY","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1058981324000225","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PEDIATRICS","Score":null,"Total":0}
Long-term follow-up of cardiopulmonary function and cardioechographic examinations in patients with repaired tetralogy of Fallot
Background
Tetralogy of Fallot (TOF) is one of the most common cyanotic congenital heart defects and typically requires intracardiac repair to correct cardiac anomalies. Postoperative TOF patients have compromised exercise capacity, which tends to decline over time. We assessed cardiopulmonary function using serial exercise testing and echocardiographic findings from childhood to adolescence in patients with repaired TOF.
Methods
This was a retrospective study. We recruited children with TOF who underwent at least two treadmill cardiopulmonary exercise tests (CPET) (with >1-year interval between the tests) between 2005 and 2022. Serial echocardiography results were evaluated to compare long-term changes in ejection fraction and pulmonary arterial pulse wave velocity. Healthy controls who underwent serial CPETs with intervals >1 year were also recruited.
Results
A total of 86 participants and 86 age-, sex-, and body mass index-matched healthy peers were identified. Significant decreases were observed in the CPET parameters between the initial and final CPETs, including peak VO2% (p < 0.001), peak MET (p = 0.027), peak heart rate (p = 0.009), and MET at AT (p = 0.001). In comparison to the control group, the patient group exhibited inferior aerobic capacity in the initial CPET, characterized by smaller peak MET (p = 0.049), peak VO2 (p = 0.001), and peak VO2% (p < 0.001). Furthermore, a notable decline in exercise capacity was noted in the patient group during the follow-up. No significant differences were observed between the serial ejection fraction and pulmonary arterial pulse wave velocity.
Conclusions
Patients with repaired TOF had inferior exercise capacities to their healthy peers, and the peak exercise load capacities tended to decline over time. However, they were safe to engage in exercise training since the CPET results exceeded the standard for moderate-to-vigorous physical activity.
期刊介绍：
Progress in Pediatric Cardiology is an international journal of review presenting information and experienced opinion of importance in the understanding and management of cardiovascular diseases in children. Each issue is prepared by one or more Guest Editors and reviews a single subject, allowing for comprehensive presentations of complex, multifaceted or rapidly changing topics of clinical and investigative interest.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
