作为新型癌症治疗方法的分子构件和营养素

Thomas Manning , Teighlor Livingston , Capri Persaud , Akshil Patel , James Nienow
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引用次数: 0

摘要

在本发明中,Cu(II)和Fe(III)与药物分子紫杉醇(PAC)结合形成了一种新型抗癌药物。这种络合增加了紫杉醇的水溶性,改变了其结构,使抗药性机制无法识别,并增加了毒性。铜(II)物种可产生活性氧化物种(ROS),并随机结合和扭曲癌细胞内的蛋白质。铜(II)还能加速血管生成,并产生特洛伊木马效应,提高癌细胞的吸收率。该复合物的经验公式为 CuxFeyPAC1,其中 X + Y 等于 0 到 10 之间的数值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Molecular building blocks and nutrients as a novel cancer treatment

In this invention, a novel cancer drug is formed by Cu(II) and Fe(III) binding the medicinal molecule Paclitaxel (PAC). This complexation increases the water solubility of the taxane, alters the structure so resistance mechanisms do not recognize it, and adds additional toxicity. The copper (II) species can generate reactive oxidation species (ROS) and randomly bind and distort proteins within a cancer cell. Cu(II) also plays a role in accelerating angiogenesis and creates a Trojan horse effect that increases its uptake rate by the cancer cells. The empirical formula for the complex is CuxFeyPAC1, where X + Y equals a value between 0 and 10.

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