星形胶质细胞在脑梗塞中的功能及潜在治疗方法

IF 1.3 Q4 CLINICAL NEUROLOGY
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引用次数: 0

摘要

星形胶质细胞是中枢神经系统中最常见的细胞,对大脑的正常生理功能起着重要作用。脑梗塞发生后,这些星形胶质细胞会发生活化,转变为反应性星形胶质细胞,最终形成胶质疤痕。这些疤痕在错综复杂的脑损伤过程中起着至关重要的作用。鉴于星形胶质细胞参与神经保护、疤痕调节、促进神经再生、保护血脑屏障、促进血管生成以及调节脑梗塞后的免疫反应,研究人员提出了一系列针对星形胶质细胞的治疗策略。本综述深入探讨了反应性星形胶质细胞在脑梗塞中的有益功能,并利用这些见解探讨了相应的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The function of astrocytes in cerebral infarction and potential therapeutic approaches

Astrocytes, the most prevalent cells in the central nervous system, significantly contribute to the normal physiological functions of the brain. Following cerebral infarction, these astrocytes undergo activation, transforming into reactive astrocytes, ultimately leading to the formation of glial scars. These scars play a crucial role in the intricate process of brain injury. Given their involvement in neuroprotection, regulation of scarring, facilitation of nerve regeneration, preservation of the blood–brain barrier, promotion of angiogenesis, and modulation of the immune response post-cerebral infarction, researchers have proposed an array of therapeutic strategies directed towards targeting astrocytes. This review delves into the beneficial functions of reactive astrocytes in the context of cerebral infarction, exploring corresponding treatment strategies that capitalize on these insights.

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来源期刊
Brain Hemorrhages
Brain Hemorrhages Medicine-Surgery
CiteScore
2.90
自引率
0.00%
发文量
52
审稿时长
22 days
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