{"title":"星形胶质细胞在脑梗塞中的功能及潜在治疗方法","authors":"","doi":"10.1016/j.hest.2024.03.003","DOIUrl":null,"url":null,"abstract":"<div><p>Astrocytes, the most prevalent cells in the central nervous system, significantly contribute to the normal physiological functions of the brain. Following cerebral infarction, these astrocytes undergo activation, transforming into reactive astrocytes, ultimately leading to the formation of glial scars. These scars play a crucial role in the intricate process of brain injury. Given their involvement in neuroprotection, regulation of scarring, facilitation of nerve regeneration, preservation of the blood–brain barrier, promotion of angiogenesis, and modulation of the immune response post-cerebral infarction, researchers have proposed an array of therapeutic strategies directed towards targeting astrocytes. This review delves into the beneficial functions of reactive astrocytes in the context of cerebral infarction, exploring corresponding treatment strategies that capitalize on these insights.</p></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589238X24000275/pdfft?md5=97c07c3deb9e7c708852b39677f97660&pid=1-s2.0-S2589238X24000275-main.pdf","citationCount":"0","resultStr":"{\"title\":\"The function of astrocytes in cerebral infarction and potential therapeutic approaches\",\"authors\":\"\",\"doi\":\"10.1016/j.hest.2024.03.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Astrocytes, the most prevalent cells in the central nervous system, significantly contribute to the normal physiological functions of the brain. Following cerebral infarction, these astrocytes undergo activation, transforming into reactive astrocytes, ultimately leading to the formation of glial scars. These scars play a crucial role in the intricate process of brain injury. Given their involvement in neuroprotection, regulation of scarring, facilitation of nerve regeneration, preservation of the blood–brain barrier, promotion of angiogenesis, and modulation of the immune response post-cerebral infarction, researchers have proposed an array of therapeutic strategies directed towards targeting astrocytes. This review delves into the beneficial functions of reactive astrocytes in the context of cerebral infarction, exploring corresponding treatment strategies that capitalize on these insights.</p></div>\",\"PeriodicalId\":33969,\"journal\":{\"name\":\"Brain Hemorrhages\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2589238X24000275/pdfft?md5=97c07c3deb9e7c708852b39677f97660&pid=1-s2.0-S2589238X24000275-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Brain Hemorrhages\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2589238X24000275\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain Hemorrhages","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2589238X24000275","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
The function of astrocytes in cerebral infarction and potential therapeutic approaches
Astrocytes, the most prevalent cells in the central nervous system, significantly contribute to the normal physiological functions of the brain. Following cerebral infarction, these astrocytes undergo activation, transforming into reactive astrocytes, ultimately leading to the formation of glial scars. These scars play a crucial role in the intricate process of brain injury. Given their involvement in neuroprotection, regulation of scarring, facilitation of nerve regeneration, preservation of the blood–brain barrier, promotion of angiogenesis, and modulation of the immune response post-cerebral infarction, researchers have proposed an array of therapeutic strategies directed towards targeting astrocytes. This review delves into the beneficial functions of reactive astrocytes in the context of cerebral infarction, exploring corresponding treatment strategies that capitalize on these insights.