Alesia V. Panibrat, Alina R. Tryfanava, A. Savachka, R. Litvinovskaya, N. M. Chashchina, Corresponding Member, Vladimir N. Zhabinskii Academician, V. Khripach, О. В. Панибрат, А. Р. Трифонова, О. П. Савочка, Р. П. Литвиновская, Н. М. Чащина, Владимир Николаевич Жабинский, В. А. Хрипач
{"title":"含水杨酸、琥珀酸和吲哚乙酸的类固醇酯对肿瘤细胞生长的影响","authors":"Alesia V. Panibrat, Alina R. Tryfanava, A. Savachka, R. Litvinovskaya, N. M. Chashchina, Corresponding Member, Vladimir N. Zhabinskii Academician, V. Khripach, О. В. Панибрат, А. Р. Трифонова, О. П. Савочка, Р. П. Литвиновская, Н. М. Чащина, Владимир Николаевич Жабинский, В. А. Хрипач","doi":"10.29235/1561-8323-2024-68-1-28-35","DOIUrl":null,"url":null,"abstract":"The aim of this work is to study the effect of new derivatives of brassinosteroids – their esters with salicylic, succinic, and indolylacetic acids on the growth of tumor cells, on their distribution by cell cycle phases and determination of the type of cell death. It was shown that the activity of the new synthesized compounds differed significantly depending on the substitution nature in the steroid nucleus, amounting to <10 µM in the case of epibrassinolide and epicastasterone salicylates, simultaneously causing the cycle arrest in the G0/G1 phase, a mitochondrial potential decrease, and apoptosis of tumor cells. The results obtained indicate the high activity of salicylates, which effectively suppress the growth of the all studied types of tumors, and the prospects of finding new antitumor agents in this series of compounds.","PeriodicalId":11283,"journal":{"name":"Doklady of the National Academy of Sciences of Belarus","volume":"20 7","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of brassinosteroid esters with salicylic, succinic, and indolylacetic acids on the tumor cell growth\",\"authors\":\"Alesia V. Panibrat, Alina R. Tryfanava, A. Savachka, R. Litvinovskaya, N. M. Chashchina, Corresponding Member, Vladimir N. Zhabinskii Academician, V. Khripach, О. В. Панибрат, А. Р. Трифонова, О. П. Савочка, Р. П. Литвиновская, Н. М. Чащина, Владимир Николаевич Жабинский, В. А. Хрипач\",\"doi\":\"10.29235/1561-8323-2024-68-1-28-35\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The aim of this work is to study the effect of new derivatives of brassinosteroids – their esters with salicylic, succinic, and indolylacetic acids on the growth of tumor cells, on their distribution by cell cycle phases and determination of the type of cell death. It was shown that the activity of the new synthesized compounds differed significantly depending on the substitution nature in the steroid nucleus, amounting to <10 µM in the case of epibrassinolide and epicastasterone salicylates, simultaneously causing the cycle arrest in the G0/G1 phase, a mitochondrial potential decrease, and apoptosis of tumor cells. The results obtained indicate the high activity of salicylates, which effectively suppress the growth of the all studied types of tumors, and the prospects of finding new antitumor agents in this series of compounds.\",\"PeriodicalId\":11283,\"journal\":{\"name\":\"Doklady of the National Academy of Sciences of Belarus\",\"volume\":\"20 7\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-03-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Doklady of the National Academy of Sciences of Belarus\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.29235/1561-8323-2024-68-1-28-35\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Doklady of the National Academy of Sciences of Belarus","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.29235/1561-8323-2024-68-1-28-35","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effect of brassinosteroid esters with salicylic, succinic, and indolylacetic acids on the tumor cell growth
The aim of this work is to study the effect of new derivatives of brassinosteroids – their esters with salicylic, succinic, and indolylacetic acids on the growth of tumor cells, on their distribution by cell cycle phases and determination of the type of cell death. It was shown that the activity of the new synthesized compounds differed significantly depending on the substitution nature in the steroid nucleus, amounting to <10 µM in the case of epibrassinolide and epicastasterone salicylates, simultaneously causing the cycle arrest in the G0/G1 phase, a mitochondrial potential decrease, and apoptosis of tumor cells. The results obtained indicate the high activity of salicylates, which effectively suppress the growth of the all studied types of tumors, and the prospects of finding new antitumor agents in this series of compounds.