用于聚酯降解的天然酶和工程酶:综述

IF 15 2区 环境科学与生态学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Rey-Ting Guo, Xian Li, Yu Yang, Jian-Wen Huang, Panpan Shen, Rock Keey Liew, Chun-Chi Chen
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引用次数: 0

摘要

由于最近在生物体和环境中发现了微塑料和纳米塑料,塑料污染正成为一个重大的健康问题,这就要求采用先进的技术来清除塑料废物。在此,我们回顾了降解塑料的酶,重点是塑料特性、蛋白质工程和聚合物,如聚对苯二甲酸乙二醇酯、聚对苯二甲酸丁二醇酯、聚乳酸、聚酰胺和聚氨酯。通过实验和计算方法对天然酶和工程酶的作用机理进行了探究。通过定向进化、结构引导的合理设计和机器学习辅助策略,聚酯降解酶的性能得到了改善。改进后的酶在高温下表现出更高的稳定性,并具有定制的底物结合位点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Natural and engineered enzymes for polyester degradation: a review

Natural and engineered enzymes for polyester degradation: a review

Plastic pollution is becoming a major health issue due to the recent discovery of microplastics and nanoplastics in living organisms and the environment, calling for advanced technologies to remove plastic waste. Here we review enzymes that degrade plastics with focus on plastic properties, protein engineering and polymers such as poly(ethylene terephthalate), poly(butylene adipate-co-terephthalate), poly(lactic acid), polyamide and polyurethane. The mechanism of action of natural and engineered enzymes has been probed by experimental and computation approaches. The performance of polyester-degrading enzymes has been improved via directed evolution, structure-guided rational design and machine learning-aided strategies. The improved enzymes display higher stability at elevated temperatures, and tailored substrate-binding sites.

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来源期刊
Environmental Chemistry Letters
Environmental Chemistry Letters 环境科学-工程:环境
CiteScore
32.00
自引率
7.00%
发文量
175
审稿时长
2 months
期刊介绍: Environmental Chemistry Letters explores the intersections of geology, chemistry, physics, and biology. Published articles are of paramount importance to the examination of both natural and engineered environments. The journal features original and review articles of exceptional significance, encompassing topics such as the characterization of natural and impacted environments, the behavior, prevention, treatment, and control of mineral, organic, and radioactive pollutants. It also delves into interfacial studies involving diverse media like soil, sediment, water, air, organisms, and food. Additionally, the journal covers green chemistry, environmentally friendly synthetic pathways, alternative fuels, ecotoxicology, risk assessment, environmental processes and modeling, environmental technologies, remediation and control, and environmental analytical chemistry using biomolecular tools and tracers.
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