二氧化锗与 2-氨基-3-羟基丁酸络合物的合成、结构和生物活性

Alena V. Kadomtseva, Georgy M. Mochalov, M. A. Zasovskaya, Anatoly M. Ob’edkov
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摘要

目前,一个很有前途的研究方向是在药典中使用具有生物活性的配位化合物,并在此基础上创造有效的杀菌药物、生物材料和酶调节剂。本文研究了一种含有 2-氨基-3-羟基丁酸的配位锗化合物。论文概述了该化合物在医药领域的应用前景。这项工作旨在解决有关合成具有广泛作用的生物活性化合物的问题。通过计算和实验方法确定了配位化合物的结构和组成。研究了含锗化合物对多种细菌和微小真菌的杀生(杀菌和杀真菌)活性。利用量子化学方法和密度泛函理论(DFT,B3LYP/6-311++G(2d,2p))计算了该化合物的理论红外光谱。通过计算,确定了配位化合物的结构以及合成过程各个阶段的中间产物的结构。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synthesis, Structure, and Biological Activity of the Germanium Dioxide Complex Compound with 2-Amino-3-Hydroxybutanoic Acid
Currently, a promising direction of study is the use of biologically active coordination compounds in the pharmacopoeia and the creation of effective bactericidal drugs, biomaterials, and enzyme modulators on that basis. The paper considers a coordination germanium compound with 2-amino-3-hydroxybutanoic acid. The prospects for the use of the compound in medicine are outlined. This work is aimed at solving the problems regarding the synthesis of biologically active compounds with a wide spectrum of actions. The structure and composition of the coordination compound have been established through calculation and experimental methods. The biocidal (bactericidal and fungicidal) activity of germanium-containing compounds against a number of bacteria and microscopic fungi has been studied. Using the quantum-chemical method with density functional theory (DFT, B3LYP/6–311++G(2d,2p)), the theoretical IR spectrum of the compound was calculated. The structure of the coordination compound and the structure of the intermediates at all stages of the synthesis process were established by calculation.
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