新的双参数 Lindley-Frailty 模型:不同基线模型下的有删减和无删减方案:应用、评估、有删失和无删失验证测试

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Samia Teghri, H. Goual, Hamami Loubna, Nadeem Shafique Butt, Abdelrahman M. Khedr, H. Yousof, M. Ibrahim, Moustafa Salem
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引用次数: 0

摘要

经典的生存模型假定易受相关事件影响的个体群体具有同质性。然而,在许多实际情况下,存在一定数量的未观察到的异质性,这些异质性可能由环境或遗传因素等多种原因造成。如果忽略了这种异质性,就会出现许多问题,包括高估危险率和不准确地估计回归系数。虚弱模型通常用来模拟个体间的异质性。本文提出了一种新的单变量虚弱模型。假定虚弱变量服从双参数 Lindley 分布。采用最大似然法估计模型参数。假定基线危险函数服从 Weibull、Exponential、Gompertz 和 Pareto 分布,并在此假设下进行了模拟研究。我们使用 Nikulin-Rao-Robson 和 Bagdonavicius-Nikulin 的拟合优度检验来确定模型的适当性,从而检验了分布的特征,并评估了其与虚弱建模中常用的其他分布相比的性能。我们分析了从阿尔及利亚一家急诊医院收集的新鲜医疗数据集,以评估所提出模型的有效性和适用性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A New Two-Parameters Lindley-Frailty Model: Censored and Uncensored Schemes under Different Baseline Models: Applications, Assessments, Censored and Uncensored Validation Testing
Classical survival models assume homogeneity among the population of individuals who are susceptible to the event of interest. However, in many practical circumstances, there is a certain amount of unobserved heterogeneity that can be caused by a variety of sources, such as environmental or genetic factors. If the heterogeneity is ignored, many issues could arise, including an overestimation of the hazard rate and inaccurate estimates of the regression coefficients. Frailty models are usually used to model the heterogeneity among individuals. In this paper, we propose a novel univariate frailty model. The frailty variable is assumed to follow the Two Parameter Lindley distribution. The maximum likelihood method is used to estimate the model parameters. The baseline hazard functions are assumed to follow Weibull, Exponential, Gompertz, and Pareto distributions, and a simulation study is performed under this assumption. We examine the characteristics of the distribution and assess its performance compared to other distributions that are frequently applied in frailty modeling by using both Nikulin-Rao-Robson and Bagdonavicius-Nikulin goodness-of-fit tests to determine the adequacy of the model. We analyze a fresh medical dataset collected from an emergency hospital in Algeria to evaluate the effectiveness and applicability of the proposed model. 
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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