呼吸道过敏中污染物佐剂的历史

IF 3.3 Q2 ALLERGY
Dennis Shusterman
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引用次数: 0

摘要

20 世纪 80 年代,过敏原和空气污染物的联合暴露成为科学界关注的一个话题,当时人们清楚地认识到,在 20 世纪,呼吸道过敏症和与交通相关的空气污染同时增加。尽管从历史上看,人们一直倾向于将与暴露有关的症状视为过敏性或毒性症状,但从那时起,这两种模式之间的交叉相互作用已经确立。例如,在接触特定过敏原的同时接触特定的空气污染物,会增加个体对该过敏原过敏的可能性,这强烈表明污染物起到了佐剂的作用。这篇小型综述虽然不是对潜在机制的综述,但其目的是强调共同暴露于佐剂化学物质在预测呼吸道过敏致敏方面的潜在意义。目前的讨论强调将上呼吸道作为呼吸道挑战研究的模型,其结果可能不仅适用于过敏性鼻炎,也适用于结膜炎和哮喘。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
History of pollutant adjuvants in respiratory allergy
Combined exposures to allergens and air pollutants emerged as a topic of concern in scientific circles by the 1980's, when it became clear that parallel increases in respiratory allergies and traffic-related air pollution had been occurring during the 20th century. Although historically there has been a tendency to treat exposure-related symptoms as either allergic or toxicologic in nature, cross-interactions have since been established between the two modalities. For example, exposure to selected air pollutants in concert with a given allergen can increase the likelihood that an individual will become sensitized to that allergen, strongly suggesting that the pollutant acted as an adjuvant. Although not a review of underlying mechanisms, the purpose of this mini-review is to highlight the potential significance of co-exposure to adjuvant chemicals in predicting allergic sensitization in the respiratory tract. The current discussion emphasizes the upper airway as a model for respiratory challenge studies, the results of which may be applicable—not only to allergic rhinitis—but also to conjunctivitis and asthma.
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来源期刊
CiteScore
2.80
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0.00%
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12 weeks
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