钯与有机席夫碱配体新型配合物的合成、表征、抗癌和抗氧化活性

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-03-12 DOI:10.4314/bcse.v38i3.5

Muhammad H. Khalil, Fuad O. Abdullah

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引用次数: 0

摘要

用氯化钯处理希夫碱 2-N-（水杨醛基）苯并噻唑（SabtH），可得到中性的 2-N-（水杨醛基）苯并噻唑钯（II）络合物。然后用一个摩尔当量的乙二胺或 1,10-菲罗啉处理，分别得到中性混合配体络合物 1 和 2。制备的有机配体及其混合配体复合物通过紫外可见光谱、傅立叶变换红外光谱、1H-NMR 和 13C-NMR 光谱进行了表征。利用 MTT 法测试了 1 和 2 对 MCF-7（乳腺癌）和 HT-29（结肠癌）癌细胞的抗增殖活性。1 对 MCF-7 和 HT-29 癌细胞都表现出很强的抗增殖活性，IC50 值分别为 74.6 ± 8.35 和 174 ± 20.28 µg/mL。此外，2 表现出最大的抗氧化活性，其 EC50 值为 1029 ± 196.76 µg/mL。关键词：2-N-（水杨醛）苯并噻唑、1,10-菲罗啉、钯混合配体配合物、抗癌、抗氧化活性 Bull.Chem.Soc.2024, 38(3), 605-613. DOI: https://dx.doi.org/10.4314/bcse.v38i3.5

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Synthesis, characterisation, and anticancer and antioxidant activities of novel complexes of palladium and an organic Schiff-base ligand

Treatment of the Schiff base 2-N-(salicylidene) benzothiazole (SabtH) with palladium chloride afforded the neutral 2-N-(salicylidene) benzothiazole palladium(II) complex. This was then treated with one molar equivalent of either ethylenediamine or 1,10-phenanthroline, yielding the neutral mixed ligand complexes 1 and 2, respectively. The prepared organic ligand and its mixed ligand complexes were characterised via UV-Vis, FTIR, 1H-NMR, and 13C-NMR spectroscopy. The antiproliferative activities of 1 and 2 were tested against MCF-7 (breast) and HT-29 (colon) cancer cells using an MTT assay. 1 showed strong antiproliferative activity against both MCF-7 and HT-29 cancer cells, with IC50 values of 74.6 ± 8.35 and 174 ± 20.28 µg/mL, respectively. In addition, 2 exhibited the maximum antioxidant activity, with an EC50 value of 1029 ± 196.76 µg/mL. KEY WORDS: 2-N-(Salicylidene) benzothiazole, 1,10-Phenanthroline, Palladium mixed ligand complexes, Anticancer, Antioxidant activity Bull. Chem. Soc. Ethiop. 2024, 38(3), 605-613. DOI: https://dx.doi.org/10.4314/bcse.v38i3.5

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.