脑源性神经营养因子对冠心病患者心血管预后的独立影响:一项前瞻性队列研究

IF 1 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
Yewei Pan, Zishan Zhang, Xuerui Tan, Jinxiu Zhu
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引用次数: 0

摘要

脑源性神经营养因子(BDNF)作为抑郁症状的生物标志物,在心血管系统中发挥着新的作用。本研究旨在揭示抑郁症状与冠心病(CHD)患者心血管预后之间的BDNF水平关联。 研究对象为2020年11月18日至2021年11月26日期间在汕头大学医学院第一附属医院住院治疗的冠心病患者。血清BDNF水平通过酶联免疫吸附试验测定。抑郁症状采用患者健康问卷(PHQ-9)进行评估。心血管事件是12个月随访的终点结果。采用卡普兰-梅耶曲线和考克斯比例危险回归模型研究血清BDNF水平与抑郁症状和预后之间的关系。 研究共纳入102名心脏病患者(60.6 ± 10.4岁,76%为男性)。根据血清BDNF水平的中位数,参与者被分为 "低BDNF(≤0.65纳克/毫升)"和 "高BDNF(≥0.65纳克/毫升)"两组。与BDNF水平高的患者相比,BDNF水平低的冠心病患者抑郁症状(PHQ-9≥10)发生率更高。在中位540天的随访中,血清BDNF水平低的患者发生心血管事件的风险增加(调整后的危险比=3.26;95%置信区间=1.18-9.02,P=0.02)。 血清BDNF水平低的冠心病患者发生心血管事件的风险显著增加,与抑郁症状无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Independent Impact of Brain-Derived Neurotrophic Factor on Cardiovascular Prognosis in Coronary Heart Disease Patients: A Prospective Cohort Study
Brain-derived neurotrophic factor (BDNF) as a biomarker of depressive symptoms manifests a novel role in the cardiovascular system. This study aims to indicate the association of BDNF levels between depressive symptoms and the cardiovascular prognosis in coronary heart disease (CHD) patients. Participants were recruited from hospitalized CHD patients between November 18, 2020 and November 26, 2021, in the First Affiliated Hospital of Shantou University Medical College. Serum BDNF levels were measured by the enzyme-linked immunosorbent assays. Depressive symptom was evaluated using Patient Health Questionnaire (PHQ-9). The cardiovascular events were the endpoint outcomes across the 12-month follow-up. Kaplan–Meier curves and Cox proportional hazards regression models were used to investigate the relationship of serum BDNF levels between depressive symptom and prognosis. A total of 102 CHD patients (60.6 ± 10.4 year, 76% male) were enrolled. Based on the median serum BDNF levels, the participants were grouped into those “low BDNF (≤0.65 ng/mL)” versus “high BDNF (≥0.65 ng/mL).” CHD patients with low BDNF levels had a higher prevalence of depressive symptoms (PHQ–9 ≥10) compared with high BDNF levels. Within a median 540 days of follow-up, low serum BDNF increased the risk of cardiovascular events (adjusted hazard ratio = 3.26; 95% confidence interval = 1.18–9.02, P = 0.02) after adjustment for confounding factors. CHD patients with low serum BDNF levels were significantly associated with an increased risk of cardiovascular events, independently of depressive symptoms.
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CiteScore
1.10
自引率
0.00%
发文量
10
审稿时长
19 weeks
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