双链 microRNA 前体

Elisabetta Scarfiello, Julian Eichlinger, Gunter Meister
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引用次数: 0

摘要

微核糖核酸(miRNA)是由茎环结构的双链核糖核酸前体在两种 RNase III 型内切核酸酶 Drosha 和 Dicer 的连续作用下生成的。然而,这种结构在细胞转录本中非常常见,而且已经进化出一些特定的特征,引导和调节茎环结构发夹加工成成熟的功能性 miRNA。这些特征包括序列基序和局部 RNA 结构,也包括 RNA 结合蛋白等反式作用因子。本综述总结了 miRNA 生物发生所需的各种特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The double-stranded microRNA precursor
MicroRNAs (miRNAs) are generated from stem-loop-structured double-stranded RNA precursors by the consecutive action of the two RNase III-type endoribonuclease Drosha and Dicer. However, such structures are very common on cellular transcripts and specific features have evolved that guide and regulate processing of stem-loop-structured hairpins into mature and functional miRNAs. These features include sequence motifs and local RNA structures but also trans-acting factors such as RNA binding proteins. The menu of features required for miRNA biogenesis is summarized in this review.
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