镁钙合金上掺锶蒙脱石涂层的体内外降解、生物相容性和骨修复性能

IF 5.6 1区医学 Q1 MATERIALS SCIENCE, BIOMATERIALS

Regenerative Biomaterials Pub Date : 2024-03-22 DOI:10.1093/rb/rbae027

Wenxin Sun, Kaining Yang, Yuhong Zou, Yande Ren, Lin Zhang, Fen Zhang, Rongchang Zeng

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引用次数: 0

摘要

骨生长不良仍然是可降解骨植入物面临的挑战。研究人员选择蒙脱石和锶作为载体和骨生长促进元素，制备了镁钙合金上的锶掺杂蒙脱石涂层。通过 SEM、EDS、XPS、FT-IR 和 XRD 对涂层的表面形貌和成分进行了表征。氢演化实验和电化学测试结果表明，涂有 Sr-MMT 涂层的镁钙合金具有最佳的耐腐蚀性能。此外，对细胞活性、ALP 活性和细胞形态的体外研究证实，Sr-MMT 涂层具有良好的生物相容性，能显著促进成骨细胞的增殖、分化和粘附。此外，大鼠 90 天植入实验结果表明，Sr-MMT 涂层的制备有效提高了镁钙合金的生物相容性和骨修复性能。此外，Sr-MMT 涂层的成骨能力可能是由于 Sr-MMT 涂层中 Si4+ 和 Sr2+ 的沉淀以及 Mg-Ca 合金降解过程中 Mg2+ 和 Ca2+ 的溶解共同作用的结果。通过使用涂层技术，该研究为具有良好耐腐蚀性和生物相容性的可生物降解镁合金提供了一种后发策略。这种新材料将为骨修复带来更多可能。

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In vitro and in vivo degradation, biocompatibility and bone repair performance of strontium doped montmorillonite coating on Mg-Ca alloy

Poor bone growth remains a challenge for degradable bone implants. Montmorillonite and strontium were selected as the carrier and bone growth promoting elements to prepare strontium doped montmorillonite coating on magnesium-calcium alloy. The surface morphology and composition were characterized by SEM, EDS, XPS, FT-IR and XRD. The hydrogen evolution experiment and electrochemical test results showed that the magnesium calcium alloy coated with Sr-MMT coating possessed optimal corrosion resistance performance. Furthermore, in vitro studies on cell activity, ALP activity, and cell morphology confirmed that Sr-MMT coating had satisfactory biocompatibility, which can significantly avail the proliferation, differentiation, and adhesion of osteoblasts. Moreover, the results of the 90 days implantation experiment in rats indicated that, the preparation of Sr-MMT coating effectively advanced the biocompatibility and bone repair performance of magnesium calcium alloy. In addition, The Osteogenic ability of Sr-MMT coating may be due to the combined effect of the precipitation of Si4+ and Sr2+ in Sr-MMT coating and the dissolution of Mg2+ and Ca2+ during the degradation of Mg-Ca alloy. By using coating technology, this study provides a late-model strategy for biodegradable Mg alloys with good corrosion resistance, biocompatibility. This new material will bring more possibilities in bone repair.

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来源期刊

Regenerative Biomaterials Materials Science-Biomaterials

CiteScore

7.90

自引率

16.40%

发文量

审稿时长

10 weeks

期刊介绍： Regenerative Biomaterials is an international, interdisciplinary, peer-reviewed journal publishing the latest advances in biomaterials and regenerative medicine. The journal provides a forum for the publication of original research papers, reviews, clinical case reports, and commentaries on the topics relevant to the development of advanced regenerative biomaterials concerning novel regenerative technologies and therapeutic approaches for the regeneration and repair of damaged tissues and organs. The interactions of biomaterials with cells and tissue, especially with stem cells, will be of particular focus.