Evaluating the Efficacy of Bromelain and Curcumin in Treating Acne Scars: A Randomized Clinical Trial

Background: Acne scars are a common dermatological condition, presenting various challenges for those affected. Thus, identifying an effective treatment for the lesions left by acne is crucial. It is hypothesized that bromelain and curcumin may be effective in treating scars owing to their anti-inflammatory properties. Objectives: This study represents the first clinical trial to evaluate the impact of a bromelain and curcumin combination on post-acne scar lesions. Methods: This was a randomized, double-blind, placebo-controlled clinical trial conducted on patients with acne scars. Patients were randomly divided into three groups (A: Bromelain-curcumin, B: Placebo, C: Bromelain-microencapsulated curcumin). Patients received either the supplement or placebo daily for one month. All three groups underwent standard AHA exfoliator treatment. After two and four weeks, the relevant questionnaires (Goodman-Baron's quantitative scoring) were completed to monitor changes in variables and to facilitate statistical analyses. Results: Seventy-six eligible patients were randomly assigned to one of the three groups. The evaluation of the investigated variables showed that patients receiving the Anaheal Plus supplement (bromelain-curcumin) experienced significant improvements in erythema and inflammation, as well as more favorable outcomes in Goodman-Baron's quantitative scoring, while no significant improvements were observed in the other groups. Conclusions: Treatment with the bromelain-curcumin supplement reduced inflammation and erythema caused by acne vulgaris after 4 weeks. This combination could be a beneficial adjunct treatment in mitigating symptoms of post-acne scarring. Further large-scale studies are needed to confirm their effectiveness in this context.