胃癌发展、诊断和治疗中的 N6-甲基化。

IF 4.7 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Journal of Translational Internal Medicine Pub Date : 2024-03-21 eCollection Date: 2024-02-01 DOI:10.2478/jtim-2023-0103

Jiaxin Wang, Guiping Zhao, Yan Zhao, Zheng Zhao, Shuyue Yang, Anni Zhou, Peng Li, Shutian Zhang

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引用次数: 0

摘要

胃癌（GC）的死亡率在全球癌症中排名第三。清楚地了解胃癌的发生和发展机制将有助于临床决策。在各种 mRNA 修饰类型中，N6-甲基腺苷（m6A）的含量最高，它调控着 RNA 代谢的多个方面。近年来，新的研究表明，m6A修饰参与了胃癌的发生和发展，并有可能成为诊断和预后的有价值的新前景。本文回顾了有关胃癌中 m6A 的最新研究进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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N⁶-methylation in the development, diagnosis, and treatment of gastric cancer.

Gastric cancer (GC) ranks third among cancers in terms of mortality rate worldwide. A clear understanding of the mechanisms underlying the genesis and progression of GC will contribute to clinical decision making. N⁶-methyladenosine (m⁶A) is the most abundant among diverse mRNA modification types and regulates multiple facets of RNA metabolism. In recent years, emerging studies have shown that m⁶A modifications are involved in gastric carcinoma tumorigenesis and progression and can potentially be valuable new prospects for diagnosis and prognosis. This article reviews the recent progress regarding m⁶A in GC.

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来源期刊

Journal of Translational Internal Medicine MEDICINE, GENERAL & INTERNAL-

CiteScore

5.50

自引率

8.20%

发文量