{"title":"通过冠状动脉计算机断层扫描血管造影评估冠状动脉粥样硬化性疾病中二尖瓣环钙化的预后价值。","authors":"Maryam Moradi, Amirabbas Shafiei Jahromi","doi":"10.4103/jrms.jrms_53_23","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>There is a lack of evidence on the link between mitral annular calcification (MAC) and coronary atherosclerotic diseases. The present investigation was undertaken to detect the clinical and prognostic value of MAC in coronary atherosclerotic diseases in patients who underwent coronary computed tomographic (CT) angiography.</p><p><strong>Materials and methods: </strong>Two hundred and five individuals with MAC and without it (<i>n</i> = 85 and 120, respectively) were included in the present cross-sectional study. Coronary artery disease-reporting and data system (CAD-RADS) at coronary CT angiography was used to define the severity of coronary atherosclerotic diseases. Patients were classified into no or non-significant CAD (CAD-RADS 0-2) and significant CAD (CAD-RADS 3-5) according to the severity of coronary atherosclerotic diseases. The association of MAC with two mentioned groups (no or non-significant CAD and significant CAD) was assessed using the Chi-squared test and logistic regression in crude and adjusted models.</p><p><strong>Results: </strong>Patients with MAC were significantly older (69.34 ± 8.20 vs. 60.64 ± 11.42, <i>P</i> < 0.001), had lower glomerular infiltration rate (69.67 ± 20.92 vs. 78.00 ± 20.23, <i>P</i> = 0.005), and higher coronary artery calcification score (352.87 ± 495.85 vs. 200.55 ± 426.13, <i>P</i> = 0.05) in comparison to those without MAC. However, the significant difference between the two groups regarding coronary artery calcification score disappeared after adjustment for confounders (<i>P</i> = 0.14). In addition, a statistically significant positive link between MAC and significant CAD was observed (odds ratio [OR] [95% confidence interval (CI)]: 1.96 [1.04-3.71], <i>P</i> = 0.04). Nevertheless, the association became statistically insignificant after adjustment for confounders (OR [95% CI]: 1.60 [0.78-3.28], <i>P</i> = 0.2).</p><p><strong>Conclusion: </strong>The findings of the study revealed that MAC has no independent prognostic value in coronary atherosclerotic diseases evaluated by coronary CT angiography.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10956555/pdf/","citationCount":"0","resultStr":"{\"title\":\"Prognostic value of mitral annular calcification in coronary atherosclerotic disease assessed by coronary computed tomographic angiography.\",\"authors\":\"Maryam Moradi, Amirabbas Shafiei Jahromi\",\"doi\":\"10.4103/jrms.jrms_53_23\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>There is a lack of evidence on the link between mitral annular calcification (MAC) and coronary atherosclerotic diseases. The present investigation was undertaken to detect the clinical and prognostic value of MAC in coronary atherosclerotic diseases in patients who underwent coronary computed tomographic (CT) angiography.</p><p><strong>Materials and methods: </strong>Two hundred and five individuals with MAC and without it (<i>n</i> = 85 and 120, respectively) were included in the present cross-sectional study. Coronary artery disease-reporting and data system (CAD-RADS) at coronary CT angiography was used to define the severity of coronary atherosclerotic diseases. Patients were classified into no or non-significant CAD (CAD-RADS 0-2) and significant CAD (CAD-RADS 3-5) according to the severity of coronary atherosclerotic diseases. The association of MAC with two mentioned groups (no or non-significant CAD and significant CAD) was assessed using the Chi-squared test and logistic regression in crude and adjusted models.</p><p><strong>Results: </strong>Patients with MAC were significantly older (69.34 ± 8.20 vs. 60.64 ± 11.42, <i>P</i> < 0.001), had lower glomerular infiltration rate (69.67 ± 20.92 vs. 78.00 ± 20.23, <i>P</i> = 0.005), and higher coronary artery calcification score (352.87 ± 495.85 vs. 200.55 ± 426.13, <i>P</i> = 0.05) in comparison to those without MAC. However, the significant difference between the two groups regarding coronary artery calcification score disappeared after adjustment for confounders (<i>P</i> = 0.14). In addition, a statistically significant positive link between MAC and significant CAD was observed (odds ratio [OR] [95% confidence interval (CI)]: 1.96 [1.04-3.71], <i>P</i> = 0.04). Nevertheless, the association became statistically insignificant after adjustment for confounders (OR [95% CI]: 1.60 [0.78-3.28], <i>P</i> = 0.2).</p><p><strong>Conclusion: </strong>The findings of the study revealed that MAC has no independent prognostic value in coronary atherosclerotic diseases evaluated by coronary CT angiography.</p>\",\"PeriodicalId\":50062,\"journal\":{\"name\":\"Journal of Research in Medical Sciences\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2024-01-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10956555/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Research in Medical Sciences\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.4103/jrms.jrms_53_23\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Research in Medical Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4103/jrms.jrms_53_23","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
摘要
背景：二尖瓣环钙化（MAC）与冠状动脉粥样硬化性疾病之间的联系尚缺乏证据。本研究旨在检测冠状动脉计算机断层扫描（CT）血管造影患者中二尖瓣环钙化对冠状动脉粥样硬化性疾病的临床和预后价值：本横断面研究共纳入 255 名患有和未患有 MAC 的患者（分别为 85 人和 120 人）。冠状动脉 CT 血管造影时使用冠状动脉疾病报告和数据系统（CAD-RADS）来定义冠状动脉粥样硬化疾病的严重程度。根据冠状动脉粥样硬化疾病的严重程度，将患者分为无或非显著性 CAD（CAD-RADS 0-2）和显著性 CAD（CAD-RADS 3-5）。在粗略模型和调整模型中，使用卡方检验和逻辑回归评估了MAC与上述两组（无或非显著CAD和显著CAD）的相关性：结果：与无 MAC 的患者相比，有 MAC 的患者年龄明显较大（69.34 ± 8.20 vs. 60.64 ± 11.42，P < 0.001），肾小球浸润率较低（69.67 ± 20.92 vs. 78.00 ± 20.23，P = 0.005），冠状动脉钙化评分较高（352.87 ± 495.85 vs. 200.55 ± 426.13，P = 0.05）。然而，在对混杂因素进行调整后，两组间冠状动脉钙化评分的显著差异消失了（P = 0.14）。此外，还观察到 MAC 与明显的 CAD 之间存在统计学意义上的显著正相关（几率比 [OR] [95% 置信区间 (CI)]：1.96 [1.04-3.71], P = 0.04).然而，在对混杂因素进行调整后，这种关联在统计学上变得不显著（OR [95% CI]：1.60 [0.78-3.28]，P = 0.2）：研究结果表明，MAC 对冠状动脉 CT 血管造影评估的冠状动脉粥样硬化性疾病没有独立的预后价值。
Prognostic value of mitral annular calcification in coronary atherosclerotic disease assessed by coronary computed tomographic angiography.
Background: There is a lack of evidence on the link between mitral annular calcification (MAC) and coronary atherosclerotic diseases. The present investigation was undertaken to detect the clinical and prognostic value of MAC in coronary atherosclerotic diseases in patients who underwent coronary computed tomographic (CT) angiography.
Materials and methods: Two hundred and five individuals with MAC and without it (n = 85 and 120, respectively) were included in the present cross-sectional study. Coronary artery disease-reporting and data system (CAD-RADS) at coronary CT angiography was used to define the severity of coronary atherosclerotic diseases. Patients were classified into no or non-significant CAD (CAD-RADS 0-2) and significant CAD (CAD-RADS 3-5) according to the severity of coronary atherosclerotic diseases. The association of MAC with two mentioned groups (no or non-significant CAD and significant CAD) was assessed using the Chi-squared test and logistic regression in crude and adjusted models.
Results: Patients with MAC were significantly older (69.34 ± 8.20 vs. 60.64 ± 11.42, P < 0.001), had lower glomerular infiltration rate (69.67 ± 20.92 vs. 78.00 ± 20.23, P = 0.005), and higher coronary artery calcification score (352.87 ± 495.85 vs. 200.55 ± 426.13, P = 0.05) in comparison to those without MAC. However, the significant difference between the two groups regarding coronary artery calcification score disappeared after adjustment for confounders (P = 0.14). In addition, a statistically significant positive link between MAC and significant CAD was observed (odds ratio [OR] [95% confidence interval (CI)]: 1.96 [1.04-3.71], P = 0.04). Nevertheless, the association became statistically insignificant after adjustment for confounders (OR [95% CI]: 1.60 [0.78-3.28], P = 0.2).
Conclusion: The findings of the study revealed that MAC has no independent prognostic value in coronary atherosclerotic diseases evaluated by coronary CT angiography.
期刊介绍：
Journal of Research in Medical Sciences, a publication of Isfahan University of Medical Sciences, is a peer-reviewed online continuous journal with print on demand compilation of issues published. The journal’s full text is available online at http://www.jmsjournal.net. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository.
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