摩洛哥小儿乳糜泻患者的免疫球蛋白E介导的食物过敏症

IF 2.5 4区 医学 Q3 ALLERGY
International Archives of Allergy and Immunology Pub Date : 2024-01-01 Epub Date: 2024-03-22 DOI:10.1159/000536282
Hasna Ait Said, Lahcen Elmoumou, Morad Guennouni, Bouchra Rherissi, Ider Oujamaa, Fatima-Ezzahra Eddehbi, Saad Lamjadli, Raja Hazime, Aïcha Bourrahouat, Imane Ait Sab, Brahim Admou, Nadia El Kadmiri
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引用次数: 0

摘要

引言乳糜泻是一种慢性自身免疫性疾病,易感基因携带者在摄入麸质后发病。乳糜泻患者,尤其是儿童,很可能对不同的食物过敏原产生过敏反应。然而,食物过敏与乳糜泻之间的关系仍未阐明。这项开创性研究的目的是评估摩洛哥乳糜泻患儿对食物过敏的发生率:共有 57 名确诊乳糜泻患儿接受了食物过敏原特异性免疫球蛋白 E (IgE) 筛查,其中男性 25 人,女性 32 人,平均年龄为 8.6 ± 4.4 岁。筛查采用多参数免疫点测定法(Euroline Food "Maghreb," Euroimmun)进行。使用 R 软件进行了统计分析:在接受检测的 57 个病例中,IgE 介导的食物过敏原致敏率为 48%(27/57),其中鸡肉占 51.9%(14/27),其次是杏仁 40.7%(11/27)、芝麻 40.7%(11/27)、土豆 33.3%(9/27)和苹果 18.5%(5/27)。在 s-IgE 阳性病例中,74% 至少对一种过敏原过敏,37%(10/27)对鸡肉和杏仁过敏原都过敏。杏仁、芝麻、鸡肉和马铃薯之间存在明显的相关性:本研究强调了乳糜泻患儿对食物过敏原过敏的高发率。结论:本研究强调了乳糜泻患儿对食物过敏的高发率,这凸显了对乳糜泻患者进行食物过敏筛查的潜在益处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Immunoglobulin E-Mediated Food Sensitization in a Moroccan Pediatric Population with Celiac Disease.

Introduction: Celiac disease is a chronic autoimmune disorder that occurs following the ingestion of gluten, in genetically predisposed individuals. Patients with celiac disease, especially children, are likely prone to develop allergic reactions to different food allergens. However, the relationship between food allergy and celiac disease remains not elucidated. The aim of this pioneering study was to evaluate the prevalence of allergic food sensitization in children with celiac disease in Morocco.

Methods: A total of 57 children with confirmed celiac disease, including 25 males and 32 females with a mean age of 8.6 ± 4.4 years, underwent a food allergen-specific immunoglobulin E (IgE) screening. This screening was conducted using a multiparametric immunodot assay (Euroline Food "Maghreb," Euroimmun). Statistical analysis was performed using R software.

Results: Among the 57 cases tested, the overall rate of IgE-mediated sensitization to food allergens was found to be 48% (27/57), dominated by chicken, with 51.9% (14/27), followed by almond, 40.7% (11/27), sesame, 40.7% (11/27), potato 33.3% (9/27), and apple 18.5% (5/27). Of the s-IgE positive cases, 74% were sensitized at least to one allergen, 37% (10/27) were sensitized to both chicken and almond allergens. A significant correlation was observed between almond, sesame, chicken, and potato.

Conclusion: The current study highlighted a high prevalence of food allergen sensitization in children with celiac disease. This underlines the potential benefit in screening for food allergy in celiac patients.

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来源期刊
CiteScore
5.60
自引率
3.60%
发文量
105
审稿时长
2 months
期刊介绍: ''International Archives of Allergy and Immunology'' provides a forum for basic and clinical research in modern molecular and cellular allergology and immunology. Appearing monthly, the journal publishes original work in the fields of allergy, immunopathology, immunogenetics, immunopharmacology, immunoendocrinology, tumor immunology, mucosal immunity, transplantation and immunology of infectious and connective tissue diseases.
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