I 组内含子：结构、剪接及其在医学真菌学中的应用。

IF 1.7 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Genetics and Molecular Biology Pub Date : 2024-03-25 eCollection Date: 2024-01-01 DOI:10.1590/1678-4685-GMB-2023-0228

Ronald Muryellison Oliveira da Silva Gomes, Kássia Jéssica Galdino da Silva, Raquel Cordeiro Theodoro

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引用次数: 0

摘要

I 组内含子是一种小型 RNA（250-500 nt），能够催化自身与前体 RNA 的剪接。它们广泛分布于生命树中，与其宿主基因组有着错综复杂的关系。在这项工作中，我们将回顾其基本结构、自我剪接及其基因移动机制。由于它们广泛存在于单细胞真核生物，尤其是真菌中，我们收集了有关它们对真菌细胞生理可能产生的影响以及这些内含子在医学真菌学中可能应用的信息。

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Group I introns: Structure, splicing and their applications in medical mycology.

Group I introns are small RNAs (250-500 nt) capable of catalyzing their own splicing from the precursor RNA. They are widely distributed across the tree of life and have intricate relationships with their host genomes. In this work, we review its basic structure, self-splicing and its mechanisms of gene mobility. As they are widely found in unicellular eukaryotes, especially fungi, we gathered information regarding their possible impact on the physiology of fungal cells and the possible application of these introns in medical mycology.

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来源期刊

Genetics and Molecular Biology 生物-生化与分子生物学

CiteScore

4.20

自引率

4.80%

发文量

111

审稿时长

3 months

期刊介绍： Genetics and Molecular Biology (formerly named Revista Brasileira de Genética/Brazilian Journal of Genetics - ISSN 0100-8455) is published by the Sociedade Brasileira de Genética (Brazilian Society of Genetics). The Journal considers contributions that present the results of original research in genetics, evolution and related scientific disciplines. Manuscripts presenting methods and applications only, without an analysis of genetic data, will not be considered.