通过过热微反应过程实现高效松脂氧化

IF 2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY
Jinpei Huang, Yongxiang Li, Yuanzheng Zhou, Yifu Yu, Jingyi Feng, Yongjun Zhang, Yifeng Zhou
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引用次数: 0

摘要

平尼克氧化法因其对敏感官能团的耐受性,被广泛应用于将α、β-不饱和醛氧化成相应羧酸的过程中。反应试剂通常包括亚氯酸钠、缓冲盐和清除剂。然而,由于反应器性能的固有限制,批量反应过程中平尼克氧化的可控性较差。这导致了潜在的安全风险,并使反应必须在低温和低浓度条件下缓慢进行。在这项工作中,我们引入了一种新的连续微反应工艺来强化平尼克氧化反应。我们选择了水溶性巴豆酸作为典型的研究对象。通过对反应参数的研究和微反应系统的构建,首次实现了高温高压条件下的高效连续反应过程。与间歇式工艺相比,该反应得益于超高温条件显著加快了反应速率,高效的气液相间传质使生成的二氧化氯得到了有效利用,微反应器的固有安全性使反应浓度得以提高。此外,平尼克氧化法中使用的缓冲盐已被盐酸成功取代,并应用于连续流。这项工作显示了微反应器在利用苛刻的反应条件实现工艺强化方面的巨大潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Efficient pinnick oxidation by a superheated micro-reaction process

Efficient pinnick oxidation by a superheated micro-reaction process

Efficient pinnick oxidation by a superheated micro-reaction process

The Pinnick oxidation, due to its tolerance for sensitive functional groups, is widely used in the process of oxidizing α,β-unsaturated aldehydes to corresponding carboxylic acids. The reaction reagents typically include sodium chlorite, buffer salts, and a scavenger. However, the controllability of Pinnick oxidation in the batch reaction process is poor due to the inherent limitations of the reactor’s performance. This leads to potential safety risks and necessitates the reaction to proceed slowly under conditions of low temperature and low concentration. In this work, we introduced a new continuous micro-reaction process to intensify the Pinnick oxidation. The water-soluble crotonic acid was selected as a typical object of study. Through the study of reaction parameters and the construction of a micro-reaction system, efficient continuous process was achieved under high-temperature and high-pressure conditions for the first time. Compared to the batch process, the reaction benefited from the superheated condition resulting in a significant acceleration of the reaction rate, efficient gas–liquid interphase mass transfer allowing for effective utilization of the generated chlorine dioxide, and the inherent safety of the microreactor enabling an increase in reaction concentration. In addition, the buffer salts used in the Pinnick oxidation has been successfully replaced by hydrochloric acid and applied to the continuous flow. This work shows the tremendous potential of microreactors in utilizing harsh reaction conditions to achieve process intensification.

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来源期刊
Journal of Flow Chemistry
Journal of Flow Chemistry CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
6.40
自引率
3.70%
发文量
29
审稿时长
>12 weeks
期刊介绍: The main focus of the journal is flow chemistry in inorganic, organic, analytical and process chemistry in the academic research as well as in applied research and development in the pharmaceutical, agrochemical, fine-chemical, petro- chemical, fragrance industry.
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