MRG15 在肝脏代谢疾病中的新作用。

IF 12.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in molecular medicine Pub Date : 2024-06-01 Epub Date: 2024-03-22 DOI:10.1016/j.molmed.2024.03.002

Cheng Tian, Xiaosong Gu, Chunping Jiang, Qiurong Ding

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引用次数: 0

摘要

MORF4（4号染色体上的死亡因子）相关基因15（MRG15）是一种染色质域蛋白，存在于参与转录、DNA修复和发育的各种多蛋白复合物中。在此，我们总结了MRG15通过其染色质结合能力或独立于染色质结合能力调节肝脏代谢的最新进展，并强调MRG15是肝脏代谢疾病的潜在治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Emerging roles of MRG15 in liver metabolic diseases.

MORF4 (mortality factor on chromosome 4)-related gene 15 (MRG15) is a chromodomain protein that exists in various multiprotein complexes involved in transcription, DNA repair, and development. Here we summarize the recent advances involving MRG15 in modulating liver metabolism, both through its chromatin-binding capability and independently of it, highlighting MRG15 as a potential therapeutic target for liver metabolic diseases.

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来源期刊

Trends in molecular medicine 医学-生化与分子生物学

CiteScore

24.60

自引率

0.00%

发文量

142

审稿时长

6-12 weeks

期刊介绍： Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.