蛋白质 N 端乙酰化进入降解终局

IF 81.3 1区生物学 Q1 CELL BIOLOGY

Nature Reviews Molecular Cell Biology Pub Date : 2024-03-22 DOI:10.1038/s41580-024-00723-1

Thomas Arnesen, Ine Kjosås, Nina McTiernan

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引用次数: 0

摘要

尽管N-末端乙酰化是真核生物中最常见的蛋白质修饰之一，但它对细胞的影响仍然是未知的。40 年前，N 端的性质与蛋白质的稳定性有关。在这篇评论中，我们将讨论 N 端乙酰化在保护蛋白质组不被降解方面新出现的重要作用。Thomas Arnesen 及其同事讨论了最常见的蛋白质修饰之一--N-末端乙酰化--在保护蛋白质组不被降解方面新出现的重要作用。

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Protein N-terminal acetylation is entering the degradation end game

Despite being one of the most common protein modifications in eukaryotes, the cellular effect of N-terminal acetylation remains cryptic. Four decades ago, the nature of the N terminus was linked to protein stability. In this Comment, we discuss an emerging major role of N-terminal acetylation in shielding the proteome from degradation. Thomas Arnesen and colleagues discuss an emerging major role of one of the most common protein modifications, N-terminal acetylation, in shielding the proteome from degradation.

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来源期刊

Nature Reviews Molecular Cell Biology 生物-细胞生物学

CiteScore

173.60

自引率

0.50%

发文量

118

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Molecular Cell Biology is a prestigious journal that aims to be the primary source of reviews and commentaries for the scientific communities it serves. The journal strives to publish articles that are authoritative, accessible, and enriched with easily understandable figures, tables, and other display items. The goal is to provide an unparalleled service to authors, referees, and readers, and the journal works diligently to maximize the usefulness and impact of each article. Nature Reviews Molecular Cell Biology publishes a variety of article types, including Reviews, Perspectives, Comments, and Research Highlights, all of which are relevant to molecular and cell biologists. The journal's broad scope ensures that the articles it publishes reach the widest possible audience.