将狐黄素作为一种有前途的生物活性化合物用于药物开发的系统综述

IF 1.3 4区 生物学 Q4 CHEMISTRY, MEDICINAL
HS Kumarasinghe , MDTL Gunathilaka
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引用次数: 0

摘要

岩藻黄素是一种存在于褐色海藻中的独特类胡萝卜素,因为其结构中存在异烯键。它的化学成分包括一个环状中心核、许多共轭双键和几个官能团。它已被证明具有多种健康优势,对糖尿病、肝硬化、肥胖症和恶性肿瘤等疾病具有保护作用。因此,狐黄素可作为一种强有力的药物和膳食成分,用于阻止各种感染性疾病的传播。本综述重点介绍了有关狐黄素药物特性的最新研究,包括抗菌、抗氧化、抗炎、皮肤保护、抗肥胖、抗糖尿病等特性,包括生物利用度和稳定性特征。本综述旨在为未来的生化研究提供支持,以便开发新的药物和膳食补充剂,使其与岩藻黄质及其多种代谢物一起发挥作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A systematic review of fucoxanthin as a promising bioactive compound in drug development

A systematic review of fucoxanthin as a promising bioactive compound in drug development

Fucoxanthin is a unique carotenoid present in brown seaweed due to the presence of an allenic bond in its structure. Its chemical composition consists of a central core that is cyclic, many conjugated double bonds, and several functional groups. Fucoxanthin plays a critical role in photosynthesis, absorbing light energy and transferring it to chlorophyll a. It has been demonstrated to have a variety of health advantages as well as protective effects against conditions including diabetes, liver cirrhosis, obesity, and malignant cancer, etc. Therefore, fucoxanthin can be employed as a strong pharmaceutical and dietary components to stop the spread of a wide array of infectious disorders. The present review focuses on the most recent research related to the pharmaceutical properties of fucoxanthin including antibacterial, antioxidant, anti-inflammatory, skin-protective, anti-obesity, anti-diabetic, and other qualities, including bioavailability and stability traits. This review seeks to support future biochemical research in order to create new pharmaceutical and dietary supplements that work with fucoxanthin and its many metabolites.

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来源期刊
Phytochemistry Letters
Phytochemistry Letters 生物-生化与分子生物学
CiteScore
3.00
自引率
11.80%
发文量
190
审稿时长
34 days
期刊介绍: Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
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